Worldwide emergence of extensively drug-resistant tuberculosis

N. Sarita Shah*, Abigail Wright, Gill Han Bai, Lucia Barrera, Fadila Boulahbal, Nuria Martín-Casabona, Francis Drobniewski, Chris Gilpin, Marta Havelková, Rosario Lepe, Richard Lumb, Beverly Metchock, Françoise Portaels, Maria Filomena Rodrigues, Sabine Rüsch-Gerdes, Armand Van Deun, Veronique Vincent, Kayla Laserson, Charles Wells, J. Peter Cegielski

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    465 Citations (Scopus)

    Abstract

    Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to ≥3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.

    Original languageEnglish
    Pages (from-to)380-387
    Number of pages8
    JournalEmerging Infectious Diseases
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - Mar 2007

    Bibliographical note

    Copyright:
    Copyright 2017 Elsevier B.V., All rights reserved.

    Fingerprint

    Dive into the research topics of 'Worldwide emergence of extensively drug-resistant tuberculosis'. Together they form a unique fingerprint.

    Cite this