Worldwide emergence of extensively drug-resistant tuberculosis

N. Sarita Shah*, Abigail Wright, Gill Han Bai, Lucia Barrera, Fadila Boulahbal, Nuria Martín-Casabona, Francis Drobniewski, Chris Gilpin, Marta Havelková, Rosario Lepe, Richard Lumb, Beverly Metchock, Françoise Portaels, Maria Filomena Rodrigues, Sabine Rüsch-Gerdes, Armand Van Deun, Veronique Vincent, Kayla Laserson, Charles Wells, J. Peter Cegielski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

435 Citations (Scopus)


Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to ≥3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalEmerging Infectious Diseases
Issue number3
Publication statusPublished - Mar 2007

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