TY - JOUR
T1 - Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB
AU - Romm, Horst
AU - Ainsbury, Elizabeth A.
AU - Barquinero, Joan Francesc
AU - Barrios, Leonardo
AU - Beinke, Christina
AU - Cucu, Alexandra
AU - Domene, Mercedes Moreno
AU - Filippi, Silvia
AU - Monteiro Gil, Octávia
AU - Gregoire, Eric
AU - Hadjidekova, Valeria
AU - Hatzi, Vasia
AU - Lindholm, Carita
AU - M´kacher, Radhia
AU - Montoro, Alegria
AU - Moquet, Jayne
AU - Noditi, Mihaela
AU - Oestreicher, Ursula
AU - Palitti, Fabrizio
AU - Pantelias, Gabriel
AU - Prieto, María Jesús
AU - Popescu, Irina
AU - Rothkamm, Kai
AU - Sebastià, Natividad
AU - Sommer, Sylwester
AU - Terzoudi, Georgia
AU - Testa, Antonella
AU - Wojcik, Andrzej
N1 - Funding Information:
We are very grateful for the extremely efficient and thoughtful technical and organizational work performed by Martina Denk, Claudia Kerscher and Jennifer Reis. This work was supported by the EU within the 7th Framework Programme [EURATOM grant agreement No. 295513].
Publisher Copyright:
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.
AB - Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.
KW - Web based scoring
KW - biodosimetry network
KW - biological dosimetry
KW - dicentric assay
KW - radiation
UR - http://www.scopus.com/inward/record.url?scp=84983543600&partnerID=8YFLogxK
U2 - 10.1080/09553002.2016.1206228
DO - 10.1080/09553002.2016.1206228
M3 - Article
C2 - 27547893
AN - SCOPUS:84983543600
VL - 93
SP - 110
EP - 117
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
SN - 0955-3002
IS - 1
ER -