Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB

Horst Romm*, Elizabeth A. Ainsbury, Joan Francesc Barquinero, Leonardo Barrios, Christina Beinke, Alexandra Cucu, Mercedes Moreno Domene, Silvia Filippi, Octávia Monteiro Gil, Eric Gregoire, Valeria Hadjidekova, Vasia Hatzi, Carita Lindholm, Radhia M´kacher, Alegria Montoro, Jayne Moquet, Mihaela Noditi, Ursula Oestreicher, Fabrizio Palitti, Gabriel PanteliasMaría Jesús Prieto, Irina Popescu, Kai Rothkamm, Natividad Sebastià, Sylwester Sommer, Georgia Terzoudi, Antonella Testa, Andrzej Wojcik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalInternational Journal of Radiation Biology
Volume93
Issue number1
DOIs
Publication statusPublished - 2 Jan 2017

Bibliographical note

Publisher Copyright:
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Web based scoring
  • biodosimetry network
  • biological dosimetry
  • dicentric assay
  • radiation

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