TY - JOUR
T1 - Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB
AU - Romm, Horst
AU - Ainsbury, Elizabeth A.
AU - Barquinero, Joan Francesc
AU - Barrios, Leonardo
AU - Beinke, Christina
AU - Cucu, Alexandra
AU - Domene, Mercedes Moreno
AU - Filippi, Silvia
AU - Monteiro Gil, Octávia
AU - Gregoire, Eric
AU - Hadjidekova, Valeria
AU - Hatzi, Vasia
AU - Lindholm, Carita
AU - M´kacher, Radhia
AU - Montoro, Alegria
AU - Moquet, Jayne
AU - Noditi, Mihaela
AU - Oestreicher, Ursula
AU - Palitti, Fabrizio
AU - Pantelias, Gabriel
AU - Prieto, María Jesús
AU - Popescu, Irina
AU - Rothkamm, Kai
AU - Sebastià, Natividad
AU - Sommer, Sylwester
AU - Terzoudi, Georgia
AU - Testa, Antonella
AU - Wojcik, Andrzej
N1 - Publisher Copyright:
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.
AB - Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.
KW - Web based scoring
KW - biodosimetry network
KW - biological dosimetry
KW - dicentric assay
KW - radiation
UR - http://www.scopus.com/inward/record.url?scp=84983543600&partnerID=8YFLogxK
U2 - 10.1080/09553002.2016.1206228
DO - 10.1080/09553002.2016.1206228
M3 - Article
C2 - 27547893
AN - SCOPUS:84983543600
SN - 0955-3002
VL - 93
SP - 110
EP - 117
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 1
ER -