Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease

Colin M. Gelder; Keith W. Hart; O. Martin Williams; Elizabeth Lyons; Kenneth I. Welsh; Ian A. Campbell; Sara E. Marshall

doi:10.1086/315489

Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease

Colin M. Gelder^*, Keith W. Hart, O. Martin Williams, Elizabeth Lyons, Kenneth I. Welsh, Ian A. Campbell, Sara E. Marshall

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apal A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.

Original language	English
Pages (from-to)	2099-2102
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	181
Issue number	6
DOIs	https://doi.org/10.1086/315489
Publication status	Published - 2000
Externally published	Yes

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title = "Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease",

abstract = "Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apal A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.",

author = "Gelder, {Colin M.} and Hart, {Keith W.} and Williams, {O. Martin} and Elizabeth Lyons and Welsh, {Kenneth I.} and Campbell, {Ian A.} and Marshall, {Sara E.}",

year = "2000",

doi = "10.1086/315489",

language = "English",

volume = "181",

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journal = "Journal of Infectious Diseases",

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TY - JOUR

T1 - Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease

AU - Gelder, Colin M.

AU - Hart, Keith W.

AU - Williams, O. Martin

AU - Lyons, Elizabeth

AU - Welsh, Kenneth I.

AU - Campbell, Ian A.

AU - Marshall, Sara E.

PY - 2000

Y1 - 2000

N2 - Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apal A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.

AB - Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apal A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.

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DO - 10.1086/315489

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EP - 2102

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -

Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease

Abstract

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