Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease

Colin M. Gelder*, Keith W. Hart, O. Martin Williams, Elizabeth Lyons, Kenneth I. Welsh, Ian A. Campbell, Sara E. Marshall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apal A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.

Original languageEnglish
Pages (from-to)2099-2102
Number of pages4
JournalJournal of Infectious Diseases
Volume181
Issue number6
DOIs
Publication statusPublished - 2000
Externally publishedYes

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