Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Roman Wölfel; Janusz T. Paweska; Nadine Petersen; Antoinette A. Grobbelaar; Patricia A. Leman; Roger Hewson; Marie Claude Georges-Courbot; Anna Papa; Stephan Günther; Christian Drosten

doi:10.3201/eid1307.070068

Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Roman Wölfel
, Janusz T. Paweska
, Nadine Petersen
, Antoinette A. Grobbelaar
, Patricia A. Leman
, Roger Hewson
, Marie Claude Georges-Courbot
, Anna Papa
, Stephan Günther
, Christian Drosten^*

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

Original language	English
Pages (from-to)	1097-1100
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	13
Issue number	7
DOIs	https://doi.org/10.3201/eid1307.070068
Publication status	Published - Jul 2007

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title = "Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients",

abstract = "We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95\% probability (probit analysis) and was 100\% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.",

author = "Roman W{\"o}lfel and Paweska, \{Janusz T.\} and Nadine Petersen and Grobbelaar, \{Antoinette A.\} and Leman, \{Patricia A.\} and Roger Hewson and Georges-Courbot, \{Marie Claude\} and Anna Papa and Stephan G{\"u}nther and Christian Drosten",

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AU - Wölfel, Roman

AU - Paweska, Janusz T.

AU - Petersen, Nadine

AU - Grobbelaar, Antoinette A.

AU - Leman, Patricia A.

AU - Hewson, Roger

AU - Georges-Courbot, Marie Claude

AU - Papa, Anna

AU - Günther, Stephan

AU - Drosten, Christian

PY - 2007/7

Y1 - 2007/7

N2 - We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

AB - We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

UR - https://www.scopus.com/pages/publications/34447271040

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DO - 10.3201/eid1307.070068

M3 - Article

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AN - SCOPUS:34447271040

SN - 1080-6040

VL - 13

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EP - 1100

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 7

ER -

Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Abstract

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