Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Roman Wölfel; Janusz T. Paweska; Nadine Petersen; Antoinette A. Grobbelaar; Patricia A. Leman; Roger Hewson; Marie Claude Georges-Courbot; Anna Papa; Stephan Günther; Christian Drosten

doi:10.3201/eid1307.070068

Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Roman Wölfel, Janusz T. Paweska, Nadine Petersen, Antoinette A. Grobbelaar, Patricia A. Leman, Roger Hewson, Marie Claude Georges-Courbot, Anna Papa, Stephan Günther, Christian Drosten^*

^*Corresponding author for this work

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Abstract

We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

Original language	English
Pages (from-to)	1097-1100
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	13
Issue number	7
DOIs	https://doi.org/10.3201/eid1307.070068
Publication status	Published - Jul 2007

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abstract = "We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.",

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AU - Wölfel, Roman

AU - Paweska, Janusz T.

AU - Petersen, Nadine

AU - Grobbelaar, Antoinette A.

AU - Leman, Patricia A.

AU - Hewson, Roger

AU - Georges-Courbot, Marie Claude

AU - Papa, Anna

AU - Günther, Stephan

AU - Drosten, Christian

PY - 2007/7

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AB - We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

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ER -

Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Abstract

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