TY - JOUR
T1 - Virus antibody survey in different european populations indicates risk association between coxsackievirus B1 and type 1 diabetes
AU - Oikarinen, Sami
AU - Tauriainen, Sisko
AU - Hober, Didier
AU - Lucas, Bernadette
AU - Vazeou, Andriani
AU - Sioofy-Khojine, Amirbabak
AU - Bozas, Evangelos
AU - Muir, Peter
AU - Honkanen, Hanna
AU - Ilonen, Jorma
AU - Knip, Mikael
AU - Keskinen, Päivi
AU - Saha, Marja Terttu
AU - Huhtala, Heini
AU - Stanway, Glyn
AU - Bartsocas, Christos
AU - Ludvigsson, Johnny
AU - Taylor, Keith
AU - Hyöty, Heikki
PY - 2014/2
Y1 - 2014/2
N2 - Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring typespecific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.
AB - Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring typespecific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.
UR - http://www.scopus.com/inward/record.url?scp=84893045342&partnerID=8YFLogxK
U2 - 10.2337/db13-0620
DO - 10.2337/db13-0620
M3 - Article
C2 - 24009257
AN - SCOPUS:84893045342
SN - 0012-1797
VL - 63
SP - 655
EP - 662
JO - Diabetes
JF - Diabetes
IS - 2
ER -