Abstract
Background: We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods: Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results: A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity. Conclusions: Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward.
| Original language | English |
|---|---|
| Article number | ofac531 |
| Journal | Open Forum Infectious Diseases |
| Volume | 9 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2022 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Keywords
- PCR
- SARS-CoV-2
- disease severity
- respiratory virus
- rhinovirus
- surveillance
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In: Open Forum Infectious Diseases, Vol. 9, No. 11, ofac531, 01.11.2022.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
AU - Vink, Elen
AU - Davis, Chris
AU - Maclean, Alasdair
AU - Pascall, David
AU - Mcdonald, Sarah E.
AU - Gunson, Rory
AU - Hardwick, Hayley E.
AU - Oosthuyzen, Wilna
AU - Openshaw, Peter J.M.
AU - Baillie, J. Kenneth
AU - Semple, Malcolm G.
AU - Ho, Antonia
AU - Baillie, J. Kenneth
AU - Openshaw, Peter J.M.
AU - Semple, Malcolm G.
AU - Barclay, Wendy S.
AU - Bogaert, Debby
AU - Chand, Meera
AU - Chechi, Kanta
AU - Cooke, Graham S.
AU - Filipe, Ana da Silva
AU - Silva, Thushan de
AU - Docherty, Annemarie B.
AU - Correia, Gonçalo dos Santos
AU - Dumas, Marc Emmanuel
AU - Dunning, Jake
AU - Fletcher, Tom
AU - Green, Christoper A.
AU - Greenhalf, William
AU - Griffin, Julian L.
AU - Gupta, Rishi K.
AU - Harrison, Ewen M.
AU - Hiscox, Julian A.
AU - Ho, Antonia Ying Wai
AU - Holden, Karl
AU - Horby, Peter W.
AU - Ijaz, Samreen
AU - Khoo, Saye
AU - Klenerman, Paul
AU - Law, Andrew
AU - Lewis, Matthew R.
AU - Liggi, Sonia
AU - Lim, Wei Shen
AU - Maslen, Lynn
AU - Mentzer, Alexander J.
AU - Merson, Laura
AU - Meynert, Alison M.
AU - Moore, Shona C.
AU - Noursadeghi, Mahdad
AU - Olanipekun, Michael
AU - Osagie, Anthonia
AU - Palmarini, Massimo
AU - Palmieri, Carlo
AU - Paxton, William A.
AU - Pollakis, Georgios
AU - Price, Nicholas
AU - Rambaut, Andrew
AU - Robertson, David L.
AU - Russell, Clark D.
AU - Sancho-Shimizu, Vanessa
AU - Sands, Caroline J.
AU - Scott, Janet T.
AU - Sigfrid, Louise
AU - Solomon, Tom
AU - Sriskandan, Shiranee
AU - Stuart, David
AU - Summers, Charlotte
AU - Swann, Olivia V.
AU - Takats, Zoltan
AU - Takis, Panteleimon
AU - Tedder, Richard S.
AU - Thompson, A. A.Roger
AU - Thomson, Emma C.
AU - Thwaites, Ryan S.
AU - Turtle, Lance C.W.
AU - Zambon, Maria
AU - Drake, Thomas M.
AU - Fairfield, Cameron J.
AU - Knight, Stephen R.
AU - Mclean, Kenneth A.
AU - Murphy, Derek
AU - Norman, Lisa
AU - Pius, Riinu
AU - Shaw, Catherine A.
AU - Connor, Marie
AU - Dalton, Jo
AU - Gamble, Carrol
AU - Girvan, Michelle
AU - Halpin, Sophie
AU - Harrison, Janet
AU - Jackson, Clare
AU - Lee, James
AU - Marsh, Laura
AU - Plotkin, Daniel
AU - Roberts, Stephanie
AU - Saviciute, Egle
AU - Clohisey, Sara
AU - Hendry, Ross
AU - Knight, Susan
AU - Lahnsteiner, Eva
AU - Law, Andrew
AU - Leeming, Gary
AU - Norris, Lucy
AU - Scott-Brown, James
AU - Tait, Sarah
AU - Wham, Murray
AU - Clark, Richard
AU - Coutts, Audrey
AU - Donnelly, Lorna
AU - Fawkes, Angie
AU - Gilchrist, Tammy
AU - Hafezi, Katarzyna
AU - Macgillivray, Louise
AU - Maclean, Alan
AU - Mccafferty, Sarah
AU - Morrice, Kirstie
AU - Murphy, Lee
AU - Wrobel, Nicola
AU - Adeniji, Kayode
AU - Agranoff, Daniel
AU - Agwuh, Ken
AU - Ail, Dhiraj
AU - Aldera, Erin L.
AU - Alegria, Ana
AU - Allen, Sam
AU - Angus, Brian
AU - Ashish, Abdul
AU - Atkinson, Dougal
AU - Bari, Shahedal
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AU - Barrett, Nicholas
AU - Bassford, Christopher
AU - Basude, Sneha
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AU - Beadsworth, Michael
AU - Bernatoniene, Jolanta
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AU - Berry, Colin
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AU - Bothma, Pieter
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AU - Burtenshaw, Andrew
AU - Caruth, Vikki
AU - Chadwick, David
AU - Chadwick, David
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AU - Chee, Nigel
AU - Child, Jenny
AU - Chukkambotla, Srikanth
AU - Clark, Tom
AU - Collini, Paul
AU - Cosgrove, Catherine
AU - Cupitt, Jason
AU - Cutino-Moguel, Maria Teresa
AU - Dark, Paul
AU - Dawson, Chris
AU - Dervisevic, Samir
AU - Donnison, Phil
AU - Douthwaite, Sam
AU - Drummond, Andrew
AU - Durand, Ingrid
AU - Dushianthan, Ahilanadan
AU - Dyer, Tristan
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AU - Fegan, Chrisopher
AU - Finn, Adam
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AU - Gkrania-Klotsas, Effrossyni
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AU - Goldsmith, Arthur
AU - Graham, Clive
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AU - Havalda, Peter
AU - Hawcutt, Daniel B.
AU - Hobrok, Maria
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AU - Hormis, Anil
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AU - Jacobs, Michael
AU - Jain, Susan
AU - Jennings, Paul
AU - Kaliappan, Agilan
AU - Kasipandian, Vidya
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AU - Kendall, Jason
AU - Kerrison, Caroline
AU - Kerslake, Ian
AU - Koch, Oliver
AU - Koduri, Gouri
AU - Koshy, George
AU - Laha, Shondipon
AU - Laird, Steven
AU - Larkin, Susan
AU - Leiner, Tamas
AU - Lillie, Patrick
AU - Limb, James
AU - Linnett, Vanessa
AU - Little, Jeff
AU - Lyttle, Mark
AU - Macmahon, Michael
AU - Macnaughton, Emily
AU - Mankregod, Ravish
AU - Masson, Huw
AU - Matovu, Elijah
AU - Mccullough, Katherine
AU - Mcewen, Ruth
AU - Meda, Manjula
AU - Mills, Gary
AU - Minton, Jane
AU - Mirfenderesky, Mariyam
AU - Mohandas, Kavya
AU - Mok, Quen
AU - Moon, James
AU - Moore, Elinoor
AU - Morgan, Patrick
AU - Morris, Craig
AU - Mortimore, Katherine
AU - Moses, Samuel
AU - Mpenge, Mbiye
AU - Mulla, Rohinton
AU - Murphy, Michael
AU - Nagarajan, Thapas
AU - Nagel, Megan
AU - Nelson, Mark
AU - Norris, Lillian
AU - O'shea, Matthew K.
AU - Ostermann, Marlies
AU - Otahal, Igor
AU - Pais, Mark
AU - Palmieri, Carlo
AU - Panchatsharam, Selva
AU - Papakonstantinou, Danai
AU - Papineni, Padmasayee
AU - Paraiso, Hassan
AU - Patel, Brij
AU - Pattison, Natalie
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AU - Peters, Mark
AU - Phull, Mandeep
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AU - Prout, Rachel
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AU - Roberts, Mark
AU - Roberts, Devender
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AU - Rousseau, Guy
AU - Ruge, Bobby
AU - Ryan, Brendan
AU - Saluja, Taranprit
AU - Cole, Sarah
AU - Schmid, Matthias L.
AU - Shah, Aarti
AU - Shankar-Hari, Manu
AU - Shanmuga, Prad
AU - Sharma, Anil
AU - Shawcross, Anna
AU - Pooni, Jagtur Singh
AU - Sizer, Jeremy
AU - Smith, Richard
AU - Snelson, Catherine
AU - Spittle, Nick
AU - Staines, Nikki
AU - Stambach, Tom
AU - Stewart, Richard
AU - Subudhi, Pradeep
AU - Szakmany, Tamas
AU - Tatham, Kate
AU - Thomas, Jo
AU - Thompson, Chris
AU - Thompson, Robert
AU - Tridente, Ascanio
AU - Tupper-Carey, Darell
AU - Twagira, Mary
AU - Vallotton, Nick
AU - Vancheeswaran, Rama
AU - Vincent-Smith, Lisa
AU - Visuvanathan, Shico
AU - Vuylsteke, Alan
AU - Waddy, Sam
AU - Wake, Rachel
AU - Walden, Andrew
AU - Welters, Ingeborg
AU - Whitehouse, Tony
AU - Whittaker, Paul
AU - Whittington, Ashley
AU - Wijesinghe, Meme
AU - Williams, Martin
AU - Wilson, Lawrence
AU - Winchester, Stephen
AU - Wiselka, Martin
AU - Wolverson, Adam
AU - Wootton, Daniel G.
AU - Workman, Andrew
AU - Yates, Bryan
AU - Young, Peter
AU - Mcdonald, Sarah E.
AU - Shaw, Victoria
AU - Ahmed, Katie A.
AU - Armstrong, Jane A.
AU - Ashworth, Milton
AU - Asiimwe, Innocent G.
AU - Bakshi, Siddharth
AU - Barlow, Samantha L.
AU - Booth, Laura
AU - Brennan, Benjamin
AU - Bullock, Katie
AU - Carlucci, Nicola
AU - Cass, Emily
AU - Catterall, Benjamin W.A.
AU - Clark, Jordan J.
AU - Clarke, Emily A.
AU - Cole, Sarah
AU - Cooper, Louise
AU - Cox, Helen
AU - Dincarslan, Oslem
AU - Carracedo, Alejandra Doce
AU - Dunn, Chris
AU - Dyer, Philip
AU - Elliott, Angela
AU - Evans, Anthony
AU - Finch, Lorna
AU - Fisher, Lewis W.S.
AU - Flaherty, Lisa
AU - Foster, Terry
AU - Garcia-Dorival, Isabel
AU - Gunning, Philip
AU - Hartley, Catherine
AU - Holmes, Anthony
AU - Jensen, Rebecca L.
AU - Jones, Christopher B.
AU - Jones, Trevor R.
AU - Khandaker, Shadia
AU - King, Katharine
AU - Kiy, Robyn T.
AU - Koukorava, Chrysa
AU - Lake, Annette
AU - Lant, Suzannah
AU - Latawiec, Diane
AU - Lavelle-Langham, Lara
AU - Lefteri, Daniella
AU - Lett, Lauren
AU - Livoti, Lucia A.
AU - Mancini, Maria
AU - Massey, Hannah
AU - Maziere, Nicole
AU - Mcdonald, Sarah
AU - Mcevoy, Laurence
AU - Mclauchlan, John
AU - Metelmann, Soeren
AU - Miah, Nahida S.
AU - Middleton, Joanna
AU - Mitchell, Joyce
AU - Moore, Shona C.
AU - Murphy, Ellen G.
AU - Penrice-Randal, Rebekah
AU - Pilgrim, Jack
AU - Prince, Tessa
AU - Reynolds, Will
AU - Ridley, P. Matthew
AU - Sales, Debby
AU - Shaw, Victoria E.
AU - Shears, Rebecca K.
AU - Small, Benjamin
AU - Subramaniam, Krishanthi S.
AU - Szemiel, Agnieska
AU - Taggart, Aislynn
AU - Tanianis-Hughes, Jolanta
AU - Thomas, Jordan
AU - Trochu, Erwan
AU - Tonder, Libby van
AU - Wilcock, Eve
AU - Zhang, J. Eunice
AU - Keating, Seán
AU - Donegan, Cara
AU - Spencer, Rebecca G.
AU - Donohue, Chloe
AU - Griffiths, Fiona
AU - Hardwick, Hayley
AU - Oosthuyzen, Wilna
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Background: We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods: Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results: A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity. Conclusions: Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward.
AB - Background: We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods: Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results: A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity. Conclusions: Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward.
KW - PCR
KW - SARS-CoV-2
KW - disease severity
KW - respiratory virus
KW - rhinovirus
KW - surveillance
UR - http://www.scopus.com/inward/record.url?scp=85145101450&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofac531
DO - 10.1093/ofid/ofac531
M3 - Article
AN - SCOPUS:85145101450
SN - 2328-8957
VL - 9
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 11
M1 - ofac531
ER -