Vaccination of healthcare workers to protect patients at increased risk of acute respiratory disease: Summary of a systematic review

Gayle Dolan*, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi Sheng Chao, Sergey Eremin, Sara Martins, John Tam, Javier Peñalver, Arina Zanuzadana, Jonathan Nguyen-van-Tam

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    19 Citations (Scopus)


    Healthcare workers (HCWs) are at increased risk of exposure to respiratory pathogens and may transmit infection to vulnerable patients. This study summarises a recent systematic review, which aimed to assess evidence that influenza or pneumococcal vaccination of HCWs provides indirect protection for those patients most at risk of severe or complicated acute respiratory infection. A number of healthcare databases and sources of grey literature were searched using a predefined strategy, and citations screened for eligibility in accordance with specified inclusion criteria. Risk of bias was assessed using validated tools and results summarised qualitatively. Twenty papers were included in the final review, all of which considered influenza vaccination of HCW. As such, planned subanalysis of pneumococcal vaccination was discarded. The majority of primary research studies included (11/14) were conducted in long-term care facilities, but there was marked heterogeneity in terms of the population, intervention/exposure and outcomes considered. Consistency in the direction of effect was observed across several different outcome measures, suggesting that influenza vaccination of HCWs is likely to offer some protection. Further evidence is, however, required from acute care settings.

    Original languageEnglish
    Pages (from-to)93-96
    Number of pages4
    JournalInfluenza and other Respiratory Viruses
    Issue numberSUPPL.2
    Publication statusPublished - 2013


    • Human
    • Influenza
    • Medical staff
    • Patients
    • Public health
    • Transmission
    • Vaccination


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