Using genomics to understand meticillin-and vancomycin-resistant staphylococcus aureus infections

Stefano G. Giulieri*, Steven Y.C. Tong, Deborah A. Williamson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community.

Original languageEnglish
Article number000324
JournalMicrobial Genomics
Volume6
Issue number1
DOIs
Publication statusPublished - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Authors.

Keywords

  • Antibiotic resistance
  • Genomics
  • MRSA
  • Staphylococcus aureus
  • Vancomycin

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