Use of whole-genome sequencing in the investigation of a nosocomial influenza virus outbreak

Catherine F. Houlihan; Dan Frampton; R. Bridget Ferns; Jade Raffle; Paul Grant; Myriam Reidy; Leila Hail; Kirsty Thomson; Frank Mattes; Zisis Kozlakidis; Deenan Pillay; Andrew Hayward; Eleni Nastouli

doi:10.1093/infdis/jiy335

Use of whole-genome sequencing in the investigation of a nosocomial influenza virus outbreak

Catherine F. Houlihan, Dan Frampton, R. Bridget Ferns, Jade Raffle, Paul Grant, Myriam Reidy, Leila Hail, Kirsty Thomson, Frank Mattes, Zisis Kozlakidis, Deenan Pillay, Andrew Hayward, Eleni Nastouli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.

Original language	English
Pages (from-to)	1485-1489
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	218
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiy335
Publication status	Published - 22 Sept 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License

Keywords

Influenza
Nosocomial
Sequencing
Transmission

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10.1093/infdis/jiy335

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title = "Use of whole-genome sequencing in the investigation of a nosocomial influenza virus outbreak",

abstract = "Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.",

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AU - Frampton, Dan

AU - Bridget Ferns, R.

AU - Raffle, Jade

AU - Grant, Paul

AU - Reidy, Myriam

AU - Hail, Leila

AU - Thomson, Kirsty

AU - Mattes, Frank

AU - Kozlakidis, Zisis

AU - Pillay, Deenan

AU - Hayward, Andrew

AU - Nastouli, Eleni

N1 - Publisher Copyright: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License

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Y1 - 2018/9/22

N2 - Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.

AB - Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.

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KW - Sequencing

KW - Transmission

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Use of whole-genome sequencing in the investigation of a nosocomial influenza virus outbreak

Abstract

Bibliographical note

Keywords

Access to Document

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