Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates

J. W. Stather, G. N. Stradling, S. A. Gray, J. Moody, A. Hodgson

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    This study has shown that: 1. both inhaled (2 μmol/kg) and injected (30 μmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of 238Pu and 241Am inhaled as nitrate to about 1% of that in untreated controls; 2. injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238Pu and 241Am in the liver and skeleton; 3. combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.

    Original languageEnglish
    Pages (from-to)573-582
    Number of pages10
    JournalHuman Toxicology
    Volume4
    Issue number6
    DOIs
    Publication statusPublished - 1985

    Fingerprint

    Dive into the research topics of 'Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates'. Together they form a unique fingerprint.

    Cite this