Use of antiviral drugs to reduce household transmission of pandemic (H1N1) 2009, United Kingdom

Richard Pebody, Ross Harris, George Kafatos, Mary Chamberland, Colin Campbell, Jonathan Nguyen-van-Tam, Estelle Mclean, Nicholas Andrews, Peter White, Edward Wynne-Evans, Jonathan Green, Joanna Ellis, Timothy Wreghitt, Samantha Bracebridge, Chikwe Ihekweazu, Isabel Oliver, Gillian Smith, Colin Hawkins, Roland Salmon, Brian SmythJim Mcmenamin, Maria Zambon, Nicholas Phin, John Watson

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40 Citations (Scopus)


The United Kingdom implemented a containment strategy for pandemic (H1N1) 2009 through administering antiviral agents (AVs) to patients and their close contacts. This observational household cohort study describes the effect of AVs on household transmission. We followed 285 confirmed primary cases in 259 households with 761 contacts. At 2 weeks, the confirmed secondary attack rate (SAR) was 8.1% (62/761) and significantly higher in persons <16 years of age than in those >50 years of age (18.9% vs. 1.2%, p<0.001). Early (<48 hours) treatment of primary case-patients reduced SAR (4.5% vs. 10.6%, p = 0.003). The SAR in child contacts was 33.3% (10/30) when the primary contact was a woman and 2.9% (1/34) when the primary contact was a man (p = 0.010). Of 53 confirmed secondary case-patients, 45 had not received AV prophylaxis. The effectiveness of AV prophylaxis in preventing infection was 92%.

Original languageEnglish
Pages (from-to)990-999
Number of pages10
JournalEmerging Infectious Diseases
Issue number6
Publication statusPublished - Jun 2011


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