Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.

E. J. Kuijper; F. Barbut; J. S. Brazier; N. Kleinkauf; T. Eckmanns; M. L. Lambert; D. Drudy; F. Fitzpatrick; C. Wiuff; D. J. Brown; J. E. Coia; H. Pituch; P. Reichert; J. Even; J. Mossong; A. F. Widmer; K. E. Olsen; F. Allerberger; D. W. Notermans; M. Delmée; B. Coignard; M. Wilcox; B. Patel; R. Frei; E. Nagy; E. Bouza; M. Marin; T. Akerlund; A. Virolainen-Julkunen; O. Lyytikäinen; S. Kotila; A. Ingebretsen; B. Smyth; P. Rooney; I. R. Poxton; D. L. Monnet

Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.

E. J. Kuijper^*, F. Barbut, J. S. Brazier, N. Kleinkauf, T. Eckmanns, M. L. Lambert, D. Drudy, F. Fitzpatrick, C. Wiuff, D. J. Brown, J. E. Coia, H. Pituch, P. Reichert, J. Even, J. Mossong, A. F. Widmer, K. E. Olsen, F. Allerberger, D. W. Notermans, M. DelméeB. Coignard, M. Wilcox, B. Patel, R. Frei, E. Nagy, E. Bouza, M. Marin, T. Akerlund, A. Virolainen-Julkunen, O. Lyytikäinen, S. Kotila, A. Ingebretsen, B. Smyth, P. Rooney, I. R. Poxton, D. L. Monnet

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

246 Citations (Scopus)

Abstract

Outbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence of a new, hypervirulent C. difficile strain in North America and Europe. This emerging strain is referred to as PCR ribotype 027 (Type 027). Since 2005, individual countries have developed surveillance studies about the spread of type 027.C. difficile Type 027 has been reported in 16 European countries. It has been responsible for outbreaks in Belgium, Germany, Finland, France, Ireland, Luxembourg, The Netherlands, Switzerland and the United Kingdom (England, Wales, Northern Ireland and Scotland). It has also been detected in Austria, Denmark, Sweden, Norway, Hungary, Poland and Spain. Three countries experienced imported patients with CDI due to Type 027 who acquired the infection abroad.The antimicrobial resistance pattern is changing, and outbreaks due to clindamycin-resistant ermB positive Type 027 strains have occurred in three European countries. Ongoing epidemiological surveillance of cases of CDI, with periodic characterisation of the strains involved, is required to detect clustering of cases in time and space and to monitor the emergence of new, highly virulent clones.

Original language	English
Journal	Eurosurveillance
Volume	13
Issue number	31
Publication status	Published - 31 Jul 2008
Externally published	Yes

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Kuijper, E. J., Barbut, F., Brazier, J. S., Kleinkauf, N., Eckmanns, T., Lambert, M. L., Drudy, D., Fitzpatrick, F., Wiuff, C., Brown, D. J., Coia, J. E., Pituch, H., Reichert, P., Even, J., Mossong, J., Widmer, A. F., Olsen, K. E., Allerberger, F., Notermans, D. W., ... Monnet, D. L. (2008). Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Eurosurveillance, 13(31).

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title = "Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.",

abstract = "Outbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence of a new, hypervirulent C. difficile strain in North America and Europe. This emerging strain is referred to as PCR ribotype 027 (Type 027). Since 2005, individual countries have developed surveillance studies about the spread of type 027.C. difficile Type 027 has been reported in 16 European countries. It has been responsible for outbreaks in Belgium, Germany, Finland, France, Ireland, Luxembourg, The Netherlands, Switzerland and the United Kingdom (England, Wales, Northern Ireland and Scotland). It has also been detected in Austria, Denmark, Sweden, Norway, Hungary, Poland and Spain. Three countries experienced imported patients with CDI due to Type 027 who acquired the infection abroad.The antimicrobial resistance pattern is changing, and outbreaks due to clindamycin-resistant ermB positive Type 027 strains have occurred in three European countries. Ongoing epidemiological surveillance of cases of CDI, with periodic characterisation of the strains involved, is required to detect clustering of cases in time and space and to monitor the emergence of new, highly virulent clones.",

author = "Kuijper, {E. J.} and F. Barbut and Brazier, {J. S.} and N. Kleinkauf and T. Eckmanns and Lambert, {M. L.} and D. Drudy and F. Fitzpatrick and C. Wiuff and Brown, {D. J.} and Coia, {J. E.} and H. Pituch and P. Reichert and J. Even and J. Mossong and Widmer, {A. F.} and Olsen, {K. E.} and F. Allerberger and Notermans, {D. W.} and M. Delm{\'e}e and B. Coignard and M. Wilcox and B. Patel and R. Frei and E. Nagy and E. Bouza and M. Marin and T. Akerlund and A. Virolainen-Julkunen and O. Lyytik{\"a}inen and S. Kotila and A. Ingebretsen and B. Smyth and P. Rooney and Poxton, {I. R.} and Monnet, {D. L.}",

year = "2008",

month = jul,

day = "31",

language = "English",

volume = "13",

journal = "Eurosurveillance",

issn = "1025-496X",

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Kuijper, EJ, Barbut, F, Brazier, JS, Kleinkauf, N, Eckmanns, T, Lambert, ML, Drudy, D, Fitzpatrick, F, Wiuff, C, Brown, DJ, Coia, JE, Pituch, H, Reichert, P, Even, J, Mossong, J, Widmer, AF, Olsen, KE, Allerberger, F, Notermans, DW, Delmée, M, Coignard, B, Wilcox, M, Patel, B, Frei, R, Nagy, E, Bouza, E, Marin, M, Akerlund, T, Virolainen-Julkunen, A, Lyytikäinen, O, Kotila, S, Ingebretsen, A, Smyth, B, Rooney, P, Poxton, IR & Monnet, DL 2008, 'Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.', Eurosurveillance, vol. 13, no. 31.

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T1 - Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.

AU - Kuijper, E. J.

AU - Barbut, F.

AU - Brazier, J. S.

AU - Kleinkauf, N.

AU - Eckmanns, T.

AU - Lambert, M. L.

AU - Drudy, D.

AU - Fitzpatrick, F.

AU - Wiuff, C.

AU - Brown, D. J.

AU - Coia, J. E.

AU - Pituch, H.

AU - Reichert, P.

AU - Even, J.

AU - Mossong, J.

AU - Widmer, A. F.

AU - Olsen, K. E.

AU - Allerberger, F.

AU - Notermans, D. W.

AU - Delmée, M.

AU - Coignard, B.

AU - Wilcox, M.

AU - Patel, B.

AU - Frei, R.

AU - Nagy, E.

AU - Bouza, E.

AU - Marin, M.

AU - Akerlund, T.

AU - Virolainen-Julkunen, A.

AU - Lyytikäinen, O.

AU - Kotila, S.

AU - Ingebretsen, A.

AU - Smyth, B.

AU - Rooney, P.

AU - Poxton, I. R.

AU - Monnet, D. L.

PY - 2008/7/31

Y1 - 2008/7/31

N2 - Outbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence of a new, hypervirulent C. difficile strain in North America and Europe. This emerging strain is referred to as PCR ribotype 027 (Type 027). Since 2005, individual countries have developed surveillance studies about the spread of type 027.C. difficile Type 027 has been reported in 16 European countries. It has been responsible for outbreaks in Belgium, Germany, Finland, France, Ireland, Luxembourg, The Netherlands, Switzerland and the United Kingdom (England, Wales, Northern Ireland and Scotland). It has also been detected in Austria, Denmark, Sweden, Norway, Hungary, Poland and Spain. Three countries experienced imported patients with CDI due to Type 027 who acquired the infection abroad.The antimicrobial resistance pattern is changing, and outbreaks due to clindamycin-resistant ermB positive Type 027 strains have occurred in three European countries. Ongoing epidemiological surveillance of cases of CDI, with periodic characterisation of the strains involved, is required to detect clustering of cases in time and space and to monitor the emergence of new, highly virulent clones.

AB - Outbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence of a new, hypervirulent C. difficile strain in North America and Europe. This emerging strain is referred to as PCR ribotype 027 (Type 027). Since 2005, individual countries have developed surveillance studies about the spread of type 027.C. difficile Type 027 has been reported in 16 European countries. It has been responsible for outbreaks in Belgium, Germany, Finland, France, Ireland, Luxembourg, The Netherlands, Switzerland and the United Kingdom (England, Wales, Northern Ireland and Scotland). It has also been detected in Austria, Denmark, Sweden, Norway, Hungary, Poland and Spain. Three countries experienced imported patients with CDI due to Type 027 who acquired the infection abroad.The antimicrobial resistance pattern is changing, and outbreaks due to clindamycin-resistant ermB positive Type 027 strains have occurred in three European countries. Ongoing epidemiological surveillance of cases of CDI, with periodic characterisation of the strains involved, is required to detect clustering of cases in time and space and to monitor the emergence of new, highly virulent clones.

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M3 - Article

C2 - 18761903

AN - SCOPUS:62249088494

SN - 1025-496X

VL - 13

JO - Eurosurveillance

JF - Eurosurveillance

IS - 31

ER -

Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.

Abstract

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