UK vaccination schedule: Persistence of immunity to hepatitis B in children vaccinated after perinatal exposure

Tom A. Yates*, Karthikeyan Paranthaman, Ly Mee Yu, Elizabeth Davis, Sarah Lang, Scott J. Hackett, Steven B. Welch, Andrew J. Pollard, Matthew D. Snape

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Objective: To assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure. Design: Serological survey. Setting: Five UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire). Participants: Children from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following perinatal exposure. Interventions: A single booster dose of the paediatric formulation of a recombinant HBV vaccine. Main outcome measures: Titres of antibody against hepatitis B Surface Antigen (anti-HBs) measured immediately before and 21-35 days after the HBV vaccine booster. Results: Prebooster anti-HBs titres were >10 mIU/ml in 84.6% of children (n=26; 95% CI 65.1 to 95.6%). All children (n=25, 95% CI 86.3 to 100%) had titres >100 mIU/ml after the booster. Conclusions: This study of antibody persistence among UK children born to hepatitis B infected women, immunised with a 3-dose infant schedule with a toddler booster suggests sustained immunity through early childhood. These data should prompt further studies to address the need for a preschool booster. Trial registration: Eudract Number 2008-004785-98.

    Original languageEnglish
    Pages (from-to)429-433
    Number of pages5
    JournalArchives of Disease in Childhood
    Volume98
    Issue number6
    DOIs
    Publication statusPublished - Jun 2013

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