UK guideline for the use of HIV post-exposure prophylaxis 2021

Fiona Cresswell*, Kaveh Asanati, Sanjay Bhagani, Marta Boffito, Valerie Delpech, Jayne Ellis, Julie Fox, Linda Furness, Margaret Kingston, Massoud Mansouri, Amanda Samarawickrama, Kat Smithson, Alex Sparrowhawk, Paul Rafferty, Tom Roper, Laura Waters, Alison Rodger, Nadi Gupta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We present the updated British Association for Sexual Health and HIV (BASHH) guidelines for post-exposure prophylaxis (PEP) to HIV following sexual exposures, occupational exposures and other nonoccupational exposures in the community. This serves as an update to the 2015 BASHH guideline on PEP following sexual exposures and the 2008 Expert Advisory Group on AIDS guidelines on HIV PEP. We aim to provide evidence-based guidance on best clinical practice in the provision, monitoring and support of PEP for the prevention of HIV acquisition following sexual, occupational and other nonoccupational exposures in the community. The guideline covers when to prescribe PEP, what antiretroviral agents to use and how to manage PEP. This includes (i) evidence of PEP efficacy; (ii) evidence relating to individual-level efficacy of antiretroviral therapy to prevent the sexual transmission of HIV; (iii) data on the detectable (transmissible) prevalence of HIV in specific populations; (iv) risk of HIV transmission following different types of sexual and occupational exposure; (v) baseline risk assessment; (vi) drug regimens and dosing schedules; (vii) monitoring PEP; (viii) baseline and follow-up blood-borne virus testing; (ix) the role of PEP within broader HIV prevention strategies, for example, HIV pre-exposure prophylaxis (PrEP). The guideline also covers special scenarios such as PEP in pregnancy, breastfeeding and chronic hepatitis B virus infection, and when PEP should be considered in people using HIV PrEP. The guidelines are aimed at clinical professionals directly involved in PEP provision and other stakeholders in the field. A proforma to assist PEP consultations is included. A public consultation process was undertaken prior to finalizing the recommendations.

Original languageEnglish
Pages (from-to)494-545
Number of pages52
JournalHIV Medicine
Issue number5
Publication statusPublished - May 2022

Bibliographical note

Funding Information:
The writing group thanks the following for their valuable contribution to the guideline: Simon Collins (i-base), Catriona Waitt (University of Liverpool), Emily Phipps (PHE), Ellen Heinsbroek (PHE), Steve Taylor (PHE) and the Library team at Brighton and Sussex University Hospital.

Publisher Copyright:
© 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.


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