UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Siu Ha Lau; Mary E. Kaufmann; David M. Livermore; Neil Woodford; Geraldine A. Willshaw; Tom Cheasty; Katie Stamper; Suganya Reddy; John Cheesbrough; Frederick J. Bolton; Andrew J. Fox; Mathew Upton

doi:10.1093/jac/dkn380

UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Siu Ha Lau, Mary E. Kaufmann, David M. Livermore, Neil Woodford, Geraldine A. Willshaw, Tom Cheasty, Katie Stamper, Suganya Reddy, John Cheesbrough, Frederick J. Bolton, Andrew J. Fox, Mathew Upton^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

Original language	English
Pages (from-to)	1241-1244
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	62
Issue number	6
DOIs	https://doi.org/10.1093/jac/dkn380
Publication status	Published - 2008

Keywords

Extended-spectrum β-lactamases
MLST
Molecular epidemiology
Multilocus sequence typing
PFGE
UPEC
Uropathogenic Escherichia coli

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jac/dkn380

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Lau, S. H., Kaufmann, M. E., Livermore, D. M., Woodford, N., Willshaw, G. A., Cheasty, T., Stamper, K., Reddy, S., Cheesbrough, J., Bolton, F. J., Fox, A. J., & Upton, M. (2008). UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone. Journal of Antimicrobial Chemotherapy, 62(6), 1241-1244. https://doi.org/10.1093/jac/dkn380

@article{128d30dc7ec34d9ca062cecdec4b8d37,

title = "UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone",

abstract = "Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.",

keywords = "Extended-spectrum β-lactamases, MLST, Molecular epidemiology, Multilocus sequence typing, PFGE, UPEC, Uropathogenic Escherichia coli",

author = "Lau, \{Siu Ha\} and Kaufmann, \{Mary E.\} and Livermore, \{David M.\} and Neil Woodford and Willshaw, \{Geraldine A.\} and Tom Cheasty and Katie Stamper and Suganya Reddy and John Cheesbrough and Bolton, \{Frederick J.\} and Fox, \{Andrew J.\} and Mathew Upton",

year = "2008",

doi = "10.1093/jac/dkn380",

language = "English",

volume = "62",

pages = "1241--1244",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "6",

}

Lau, SH, Kaufmann, ME, Livermore, DM, Woodford, N, Willshaw, GA, Cheasty, T, Stamper, K, Reddy, S, Cheesbrough, J, Bolton, FJ, Fox, AJ & Upton, M 2008, 'UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone', Journal of Antimicrobial Chemotherapy, vol. 62, no. 6, pp. 1241-1244. https://doi.org/10.1093/jac/dkn380

TY - JOUR

T1 - UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

AU - Lau, Siu Ha

AU - Kaufmann, Mary E.

AU - Livermore, David M.

AU - Woodford, Neil

AU - Willshaw, Geraldine A.

AU - Cheasty, Tom

AU - Stamper, Katie

AU - Reddy, Suganya

AU - Cheesbrough, John

AU - Bolton, Frederick J.

AU - Fox, Andrew J.

AU - Upton, Mathew

PY - 2008

Y1 - 2008

N2 - Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

AB - Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

KW - Extended-spectrum β-lactamases

KW - MLST

KW - Molecular epidemiology

KW - Multilocus sequence typing

KW - PFGE

KW - UPEC

KW - Uropathogenic Escherichia coli

UR - https://www.scopus.com/pages/publications/56649108214

U2 - 10.1093/jac/dkn380

DO - 10.1093/jac/dkn380

M3 - Article

C2 - 18779256

AN - SCOPUS:56649108214

SN - 0305-7453

VL - 62

SP - 1241

EP - 1244

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 6

ER -

UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Abstract

Keywords

UN SDGs

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