Type-specific HPV prevalence in invasive cervical cancer in the UK prior to national HPV immunisation programme: Baseline for monitoring the effects of immunisation

David Mesher*, Kate Cuschieri, Sam Hibbitts, Jackie Jamison, Alex Sargent, Kevin G. Pollock, Ned Powell, Robbie Wilson, Fiona McCall, Alison Fiander, Katherine Soldan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Aims: To establish the human papillomavirus (HPV) type-specific prevalence in cervical cancer and high-grade cervical lesions in the UK prior to the introduction of national HPV vaccination. Methods: Specimens of cervical cancer (n=1235) and cervical intraepithelial neoplasia (CIN)3 (n=2268) were tested for HPV genotypes in England, Scotland, Wales and Northern Ireland. Data were pooled and weighted estimates presented. Results: Among cervical cancer cases, 95.8% were positive for at least one high-risk (HR) HPV type. Restricting to those with HR HPV, the proportion positive for HPV16 and/or HPV18 was similar across countries (weighted overall prevalence 83.0%). This proportion decreased with increasing age at diagnosis (p=0.0005). HPV31, HPV33, HPV45, HPV52 and/or HPV58 were detected in 16.1% of HR HPV-positive cervical cancers and there was no significant association with age for these types. For HR HPV-positive CIN3 cases, there was a similar age-specific pattern with the highest positivity of HPV16 and/or HPV18 in the youngest age group (77.2%). The proportion of HR HPV CIN3 cases positive for HPV31, HPV33, HPV45, HPV52 and/or HPV58 was 36.3% in those aged <30 years at diagnosis. Conclusions: The prevalence of HPV 16 and/or 18 was high in all UK countries and highest in those diagnosed at a younger age. The UK is well placed to monitor the impact of HPV vaccination on type-specific HPV prevalence in cervical disease.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalJournal of Clinical Pathology
Volume68
Issue number2
DOIs
Publication statusPublished - 1 Feb 2015

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© 2015, BMJ Publishing Group. All rights reserved.

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