TY - JOUR
T1 - Two linked enteroinvasive Escherichia coli outbreaks, Nottingham, UK, June 2014
AU - Newitt, Sophie
AU - MacGregor, Vanessa
AU - Robbins, Vivienne
AU - Bayliss, Laura
AU - Anne Chattaway, Marie
AU - Dallman, Tim
AU - Ready, Derren
AU - Aird, Heather
AU - Puleston, Richard
AU - Hawker, Jeremy
N1 - Publisher Copyright:
© 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2016/7
Y1 - 2016/7
N2 - Enteroinvasive Escherichia coli (EIEC) outbreaks are uncommon in Europe. In June 2014, two EIEC outbreaks occurred in Nottingham, UK, within 2 days; outbreak A was linked to a takeaway restaurant and outbreak B to a wedding party. We conducted 2 analytical studies: a case-control study for outbreak A and a cohort study for outbreak B. We tested microbiological and environmental samples, including by using whole-genome sequencing. For both outbreaks combined, we identified 157 probable case-patients; 27 were laboratory-confirmed as EIEC O96:H19-positive. Combined epidemiologic, microbiological, and environmental findings implicated lettuce as the vehicle of infection in outbreak A, but the source of the organism remained unknown. Whole-genome sequencing identified the same organism in cases from both outbreaks, but no epidemiologic link was confirmed. These outbreaks highlight that EIEC has the capacity to cause large and severe gastrointestinal disease outbreaks and should be considered as a potential pathogen in foodborne outbreaks in Europe.
AB - Enteroinvasive Escherichia coli (EIEC) outbreaks are uncommon in Europe. In June 2014, two EIEC outbreaks occurred in Nottingham, UK, within 2 days; outbreak A was linked to a takeaway restaurant and outbreak B to a wedding party. We conducted 2 analytical studies: a case-control study for outbreak A and a cohort study for outbreak B. We tested microbiological and environmental samples, including by using whole-genome sequencing. For both outbreaks combined, we identified 157 probable case-patients; 27 were laboratory-confirmed as EIEC O96:H19-positive. Combined epidemiologic, microbiological, and environmental findings implicated lettuce as the vehicle of infection in outbreak A, but the source of the organism remained unknown. Whole-genome sequencing identified the same organism in cases from both outbreaks, but no epidemiologic link was confirmed. These outbreaks highlight that EIEC has the capacity to cause large and severe gastrointestinal disease outbreaks and should be considered as a potential pathogen in foodborne outbreaks in Europe.
UR - http://www.scopus.com/inward/record.url?scp=84974851157&partnerID=8YFLogxK
U2 - 10.3201/eid2207.152080
DO - 10.3201/eid2207.152080
M3 - Article
C2 - 27314432
AN - SCOPUS:84974851157
SN - 1080-6040
VL - 22
SP - 1178
EP - 1184
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 7
ER -
