Two Japanese Corynebacterium ulcerans isolates from the same hospital: Ribotype, toxigenicity and serum antitoxin titre

Takako Komiya; Yukiji Seto; Aruni De Zoysa; Masaaki Iwaki; Akio Hatanaka; Atsunobu Tsunoda; Yoshichika Arakawa; Shunji Kozaki; Motohide Takahashi

doi:10.1099/jmm.0.022491-0

Two Japanese Corynebacterium ulcerans isolates from the same hospital: Ribotype, toxigenicity and serum antitoxin titre

Takako Komiya, Yukiji Seto, Aruni De Zoysa, Masaaki Iwaki^*, Akio Hatanaka, Atsunobu Tsunoda, Yoshichika Arakawa, Shunji Kozaki, Motohide Takahashi

^*Corresponding author for this work

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Abstract

Two toxigenic Corynebacterium ulcerans isolates recovered from pharyngeal swabs of two patients from the same hospital in Japan during 2001-2002 were characterized by PFGE and ribotyping. Toxin production in different culture media was examined and serological analysis of patient sera was performed. The two isolates could not be distinguished by PFGE; however, their ribotypes were distinguishable. One of the isolates could represent a novel ribotype. Analysis of toxin production in different culture media demonstrated that the two isolates produced varying amounts of the diphtheria toxin. Serological analysis showed a greater than sevenfold increase in the serum antitoxin titre during the course of infection in one patient.

Original language	English
Pages (from-to)	1497-1504
Number of pages	8
Journal	Journal of Medical Microbiology
Volume	59
Issue number	12
DOIs	https://doi.org/10.1099/jmm.0.022491-0
Publication status	Published - Dec 2010

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abstract = "Two toxigenic Corynebacterium ulcerans isolates recovered from pharyngeal swabs of two patients from the same hospital in Japan during 2001-2002 were characterized by PFGE and ribotyping. Toxin production in different culture media was examined and serological analysis of patient sera was performed. The two isolates could not be distinguished by PFGE; however, their ribotypes were distinguishable. One of the isolates could represent a novel ribotype. Analysis of toxin production in different culture media demonstrated that the two isolates produced varying amounts of the diphtheria toxin. Serological analysis showed a greater than sevenfold increase in the serum antitoxin titre during the course of infection in one patient.",

author = "Takako Komiya and Yukiji Seto and {De Zoysa}, Aruni and Masaaki Iwaki and Akio Hatanaka and Atsunobu Tsunoda and Yoshichika Arakawa and Shunji Kozaki and Motohide Takahashi",

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AU - Komiya, Takako

AU - Seto, Yukiji

AU - De Zoysa, Aruni

AU - Iwaki, Masaaki

AU - Hatanaka, Akio

AU - Tsunoda, Atsunobu

AU - Arakawa, Yoshichika

AU - Kozaki, Shunji

AU - Takahashi, Motohide

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Two Japanese Corynebacterium ulcerans isolates from the same hospital: Ribotype, toxigenicity and serum antitoxin titre

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