Tuberculosis and HIV co-infection in healthcare workers in England and Wales, 1999-2005

J. P. Crofts*, M. E. Kruijshaar, V. Delpech, F. Ncube, I. Abubakar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


This study used linked national tuberculosis (TB) and HIV surveillance data to investigate recent trends and factors associated with HIV co-infection (TB-HIV) in healthcare workers (HCWs) with TB in England and Wales. Methods applied were the 2 trend test and logistic regression. Overall 14% (231/1627) of HCWs with TB were co-infected with HIV, increasing from 8% in 1999 to 14% in 2005 (P<0 001). Most (78%) HCWs were non-UK born and 74% of these developed TB 2 years post-entry. Being born in Sub-Saharan Africa was an independent predictor for TB-HIV, especially for female HCWs (odds ratio 66 5, 95% confidence interval 16 3-271 1), who also had a lower median CD4 count than other co-infected women (106/mm 3, interquartile range 40-200, P<0 01). Voluntary HIV testing of new HCWs should be encouraged as an opportunity for early diagnosis. Post-entry, a high index of clinical suspicion for TB in those most at risk remains important.

Original languageEnglish
Pages (from-to)1873-1879
Number of pages7
JournalEpidemiology and Infection
Issue number10
Publication statusPublished - Oct 2012


  • Epidemiology
  • health policy
  • screening programme
  • tuberculosis (TB)


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