The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. β-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like proteases, complete with similar β-propeller, PDZ and catalytic domains. We propose various hypotheses as to the function of these domains that can now be tested in the laboratory.
Bibliographical noteFunding Information:
We thank the BBSRC for funding the ViruloGenome project. We gratefully acknowledge staff at the Sanger Centre, John Innes Centre, the Institute for Genomic Research, the University of Oklahoma and Genome Therapeutics for making incomplete genome sequence data publicly available. We thank Chris Ponting, Ian Charles, Duncan Maskell and Alastair Hawkins for stimulating our interest in this subject.