Trends in net survival from pancreatic cancer in six European Latin countries: Results from the SUDCAN population-based study

GRELL EUROCARE-5 Working Group

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    11 Citations (Scopus)

    Abstract

    Pancreatic cancer represents a real clinical challenge. The aim of the SUDCAN collaborative study was to compare the net survival from pancreatic cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland) and provide trends in net survival and dynamics of excess mortality rates up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country. Results were reported from 1992 to 2004 in France, Italy, Spain and Switzerland and from 2000 to 2004 in Belgium and Portugal. These analyses were carried out using a flexible excess rate modelling strategy. There were little differences between countries in age-standardized net survivals (2000-2004). The 5-year net survival was poor (range: 6-10%). The changes in net survival from 1992 to 2004 were mostly related to early survival and patients aged 60 years. A slight decrease in the excess mortality rate between 1992 and 2004 was observed, limited to the 18 months after diagnosis. This study confirmed that, despite some improvement, survival from pancreatic cancer is still poor throughout European Latin countries. The major improvements in clinical imaging did not result in improvements in prognosis. Development of truly innovative treatments is highly needed to improve prognosis.

    Original languageEnglish
    Pages (from-to)S63-S69
    JournalEuropean Journal of Cancer Prevention
    Volume26
    Issue numberTrends in cancer net survival in six European Latin Countries...
    DOIs
    Publication statusPublished - 2017

    Bibliographical note

    Funding Information:
    The SUDCAN study was supported by the French Ligue contre le Cancer. The authors thank Ludivine Garrier (registre des cancers digestifs de Bourgogne) for her technical assistance and Jean Iwaz (Service de Biostatistique des Hospices Civils de Lyon) for the final revision of the manuscript. The EUROCARE study was supported by The Compagnia di San Paolo, Fondazione Cariplo, the Italian Ministry of Health (Ricerca Finalizzata 2009, RF-2009-1529710) and the European Commission (European Action Against Cancer, EPAAC, Joint Action No. 20102202).

    Publisher Copyright:
    Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

    Keywords

    • Cancer registries
    • Europe
    • Excess mortality rate
    • Net survival
    • Pancreatic cancer
    • Trend analysis

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