Trends in antimicrobial drug resistance in Salmonella enterica serotypes Typhi and Paratyphi A isolated in Europe, 1999-2001

E. J. Threlfall*, Ian Fisher, C. Berghold, P. Gerner-Smidt, H. Tschäpe, M. Cormican, I. Luzzi, F. Schnieder, W. Wannet, J. Machado, G. Edwards

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Results of antimicrobial sensitivity tests for strains of Salmonella enterica serotypes Typhi and Paratyphi A isolated from patients in ten European countries between 1999 and 2001 have been transferred electronically to the Enter-net surveillance hub. For Typhi between 22 and 29% of isolates were multiresistant (to four drugs or more) with decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/l) increasing from 20% in 1999 to 26% in 2001. Nineteen of 169 (11%) strains with decreased ciprofloxacin susceptibility were sensitive to nalidixic acid. For Paratyphi A multiple resistance increased from 9% in 1999 to 25% in 2001 and decreased ciprofloxacin susceptibility from 6 to 17%. Clinicians should be aware of the possibility of treatment failures when fluoroquinolones are used as the first-line drug for infections with Typhi and Paratyphi A, particularly for patients recently returning from areas where drug-resistant strains are endemic.

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume22
Issue number5
DOIs
Publication statusPublished - Nov 2003

Bibliographical note

Funding Information:
The authors would like to acknowledge the support and contribution to the surveillance network of all the Enter-net participants. Enter-net is funded by the European Commission, Directorate General Health and Consumer Protection, Directorate G, Public Health, Unit 4—Communicable, Rare and Emerging Diseases, contract no 2000CVG4-037.

Keywords

  • Ciprofloxacin
  • Drug resistance
  • Europe
  • S. Paratyphi A
  • Salmonella Typhi

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