Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin

J. Steward*, T. Piercy, M. S. Lever, Andrew Simpson, Timothy Brooks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The efficacies of gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of pneumonic tularemia and compared with the efficacy of ciprofloxacin. The rate of relapse following dexamethasone treatment was also investigated. Mice were given 100 mg/kg of the antibiotic by oral administration twice daily for 14 days following an aerosol challenge. All three fluoroquinolones prevented disease during the treatment period, but significant failure rates occurred after the cessation of therapy. Both gatifloxacin and moxifloxacin were more effective than ciprofloxacin at reducing late mortality. Fluoroquinolones may therefore be considered useful candidates for the treatment of pneumonic tularemia. Crown

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume27
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Aerosol
  • Francisella tularensis
  • Mouse model
  • Quinolones

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