Transmission analysis of a large tuberculosis outbreak in london: A mathematical modelling study using genomic data

Yuanwei Xu, Jessica E. Stockdale, Vijay Naidu, Hollie Hatherell, James Stimson, Helen Stagg, Ibrahim Abubakar, Caroline Colijn*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)
    4 Downloads (Pure)

    Abstract

    Outbreaks of tuberculosis (TB) – such as the large isoniazid-resistant outbreak centred on London, UK, which originated in 1995 – provide excellent opportunities to model transmission of this devastating disease. Transmission chains for TB are notoriously difficult to ascertain, but mathematical modelling approaches, combined with whole-genome sequencing data, have strong potential to contribute to transmission analyses. Using such data, we aimed to reconstruct transmission histories for the outbreak using a Bayesian approach, and to use machine-learning techniques with patient-level data to identify the key covariates associated with transmission. By using our transmission reconstruction method that accounts for phylogenetic uncertainty, we are able to identify 21 transmission events with reasonable confidence, 9 of which have zero SNP distance, and a maximum distance of 3. Patient age, alcohol abuse and history of homelessness were found to be the most important predictors of being credible TB transmitters.

    Original languageEnglish
    Article number000450
    JournalMicrobial Genomics
    Volume6
    Issue number11
    DOIs
    Publication statusPublished - 11 Nov 2020

    Bibliographical note

    Funding Information: C. C., J. S. and Y. X. were supported by the Engineering and Physical Sciences Research Council of the UK (EPSRC) [EP/K026003/1 (C. C. and J.S.) and EP/N014529/1 (C.C. and Y.X.)]. H. R. S. was supported by the Medical Research Council (MR/R008345/1). H. H. was funded by an EPSRC PhD studentship. C. C. and J. E. S. were supported by the Federal Government of Canada’s Canada 150 Research Chairs programme.

    Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

    Publisher Copyright: © 2020 The Authors.

    Citation: Xu, Yuanwei, et al. "Transmission analysis of a large tuberculosis outbreak in London: a mathematical modelling study using genomic data." Microbial genomics 6.11 (2020).

    DOI: https://doi.org/10.1099/mgen.0.000450

    Keywords

    • Genomic epidemiology
    • Infectious disease
    • Machine learning
    • Modelling
    • Tuberculosis

    Fingerprint

    Dive into the research topics of 'Transmission analysis of a large tuberculosis outbreak in london: A mathematical modelling study using genomic data'. Together they form a unique fingerprint.

    Cite this