Transferrin-mediated uptake of plutonium by spermatogenic tubules

K. P. Hoyes*, D. Bingham, J. H. Hendry, John Harrison, H. L. Sharma, I. D. Morris

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.

    Original languageEnglish
    Pages (from-to)467-471
    Number of pages5
    JournalInternational Journal of Radiation Biology
    Issue number4
    Publication statusPublished - 1996

    Bibliographical note

    Funding Information:
    These studies were supported by th e United Kingdom Coordinating Com m ittee on Cancer Research and the Cancer Research Cam paign.


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