Transferrin-mediated uptake of plutonium by spermatogenic tubules

K. P. Hoyes; D. Bingham; J. H. Hendry; John Harrison; H. L. Sharma; I. D. Morris

doi:10.1080/095530096144941

Transferrin-mediated uptake of plutonium by spermatogenic tubules

K. P. Hoyes^*, D. Bingham, J. H. Hendry, John Harrison, H. L. Sharma, I. D. Morris

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Using isolated rat seminiferous tubules as an in vitro model, we have found that ²³⁸Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to ⁵⁹Fe, tubule ²³⁸Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike ⁵⁹Fe, ²³⁸Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.

Original language	English
Pages (from-to)	467-471
Number of pages	5
Journal	International Journal of Radiation Biology
Volume	70
Issue number	4
DOIs	https://doi.org/10.1080/095530096144941
Publication status	Published - 1996

Bibliographical note

Funding Information:
These studies were supported by th e United Kingdom Coordinating Com m ittee on Cancer Research and the Cancer Research Cam paign.

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abstract = "Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.",

author = "Hoyes, {K. P.} and D. Bingham and Hendry, {J. H.} and John Harrison and Sharma, {H. L.} and Morris, {I. D.}",

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AU - Hoyes, K. P.

AU - Bingham, D.

AU - Hendry, J. H.

AU - Harrison, John

AU - Sharma, H. L.

AU - Morris, I. D.

N1 - Funding Information: These studies were supported by th e United Kingdom Coordinating Com m ittee on Cancer Research and the Cancer Research Cam paign.

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AB - Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.

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Transferrin-mediated uptake of plutonium by spermatogenic tubules

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