Transferrin-mediated uptake of plutonium by spermatogenic tubules

K. P. Hoyes*, D. Bingham, J. H. Hendry, John Harrison, H. L. Sharma, I. D. Morris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalInternational Journal of Radiation Biology
Issue number4
Publication statusPublished - 1996

Bibliographical note

Funding Information:
These studies were supported by th e United Kingdom Coordinating Com m ittee on Cancer Research and the Cancer Research Cam paign.


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