TY - JOUR
T1 - Timing of monoclonal antibody for seasonal RSV prophylaxis in the United Kingdom
AU - Goddard, N. L.
AU - Cooke, M. C.
AU - Gupta, R. K.
AU - Nguyen-Van-Tam, Jonathan S.
PY - 2007/1
Y1 - 2007/1
N2 - Respiratory syncytial virus (RSV) infection produces more severe disease and increased hospitalization rates in high-risk babies. The monoclonal antibody palivizumab offers protection against complications, and the first of five monthly doses should be administered before the onset of community RSV activity. However, the required real-time prediction of this onset is problematic. We attempted to identify seasonal RSV patterns by retrospectively examining 10 years of laboratory reports for RSV and clinical episode reports for certain respiratory presentations in both primary and secondary care. Analysis of hospital laboratory reports, incidence of acute bronchitis in primary care, and hospital admissions for acute bronchitis and bronchiolitis in young children revealed a consistent increase in RSV activity during week 43 each year. Promptly commencing prophylaxis during the second week of each October (week 42) would precede the onset of the RSV season in the United Kingdom, and provide coverage until its decline in mid-March.
AB - Respiratory syncytial virus (RSV) infection produces more severe disease and increased hospitalization rates in high-risk babies. The monoclonal antibody palivizumab offers protection against complications, and the first of five monthly doses should be administered before the onset of community RSV activity. However, the required real-time prediction of this onset is problematic. We attempted to identify seasonal RSV patterns by retrospectively examining 10 years of laboratory reports for RSV and clinical episode reports for certain respiratory presentations in both primary and secondary care. Analysis of hospital laboratory reports, incidence of acute bronchitis in primary care, and hospital admissions for acute bronchitis and bronchiolitis in young children revealed a consistent increase in RSV activity during week 43 each year. Promptly commencing prophylaxis during the second week of each October (week 42) would precede the onset of the RSV season in the United Kingdom, and provide coverage until its decline in mid-March.
UR - https://www.scopus.com/pages/publications/33751383958
U2 - 10.1017/S0950268806006601
DO - 10.1017/S0950268806006601
M3 - Article
C2 - 16753078
AN - SCOPUS:33751383958
SN - 0950-2688
VL - 135
SP - 159
EP - 162
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 1
ER -
