The yeast genus Tardiomyces gen. nov. with one new species and two new combinations

Bram Spruijtenburg*, Bruna Jacomel Favoreto de Souza Lima, Sonia T.Granadillo Tosar, Andrew M. Borman, Cecilie Torp Andersen, Summiya Nizamuddin, Suhail Ahmad, João Nobrega de Almeida Junior, Vânia Aparecida Vicente, Joshua D. Nosanchuk, Jochem B. Buil, Sybren de Hoog, Eelco F.J. Meijer, Jacques F. Meis, Theun de Groot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals. Methods: To obtain more insight into the characteristics of this species, 26 isolates reported as C. blankii were investigated using genetic and phenotypical approaches. Results: Among the 26 isolates, seven recovered either from blood, sputum, urine, or the oral cavity, displayed substantial genetic and some phenotypical differences compared to the other isolates, which were confirmed as C. blankii. We consider these seven strains to represent a novel species, Tardiomyces depauwii. Phylogenomics assigned C. blankii, C. digboiensis, and the novel species in a distinct branch within the order Dipodascales, for which the novel genus Tardiomyces is erected. The new combinations Tardiomyces blankii and Tardiomyces digboiensis are introduced. Differences with related, strictly environmental genera Sugiyamaella, Crinitomyces, and Diddensiella are enumerated. All three Tardiomyces species share the rare ability to grow up to 42 °C, display slower growth in nutrient-poor media, and show a reduced susceptibility to azoles and echinocandins. Characteristics of T. depauwii include high MIC values with voriconazole and a unique protein pattern. Conclusion: We propose the novel yeast species Tardiomyces depauwii and the transfer of C. blankii and C. digboiensis to the novel Tardiomyces genus.

Original languageEnglish
JournalInfection
DOIs
Publication statusAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Keywords

  • Antifungal resistance
  • Candida blankii
  • Characterization
  • Misidentification
  • Nomenclature
  • Tardiomyces depauwii
  • Whole-genome sequencing

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