The wash-in effect and its significance for mass casualty decontamination

Thomas James, Lydia Izon-Cooper, Samuel Collins, Haydn Cole, Tim Marczylo

Research output: Contribution to journalReview articlepeer-review

5 Downloads (Pure)

Abstract

Decontamination of skin by washing may increase dermal absorption, a phenomenon known as the wash-in effect. The wash-in effect is frequently discussed in studies investigating casualty decontamination where potentially life-saving interventions may enhance the dermal penetration of toxic chemicals, leading to an increase in incidence of morbidity and rates of mortality. However, the wash-in effect is seldom investigated within the context of mass casualty decontamination and real-life consequences are therefore poorly understood. This paper reviews the existing literature on the wash-in effect to highlight the proposed mechanisms for enhanced absorption and evaluate the wash-in effect within the context of mass casualty chemical decontamination.

Original languageEnglish
Pages (from-to)113-134
Number of pages22
JournalJournal of Toxicology and Environmental Health - Part B: Critical Reviews
Volume25
Issue number3
Early online date27 Feb 2022
DOIs
Publication statusE-pub ahead of print - 27 Feb 2022

Bibliographical note

Funding Information: This work was supported by the National Institute for Health Research [NIHR130440] and part funded by the National Institute for Health Research (NIHR) Health Protection Research Unit in Chemical and Radiation Threats and Hazards, a partnership between UK Health Security Agency and Imperial College London

Open Access: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher Copyright: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

Citation: Thomas James, Lydia Izon-Cooper, Samuel Collins, Haydn Cole & Tim Marczylo (2022) The wash-in effect and its significance for mass casualty decontamination, Journal of Toxicology and Environmental Health, Part B, 25:3, 113-134,

DOI: 10.1080/10937404.2022.2042443

Keywords

  • Emergency response
  • casualty decontamination
  • chemical
  • skin penetration
  • wash-in effect

Fingerprint

Dive into the research topics of 'The wash-in effect and its significance for mass casualty decontamination'. Together they form a unique fingerprint.

Cite this