Following the uptake of curium-244 dioxide, a major factor influencing the movement of 244Cm from lungs to blood and urine is the formation and transport of 0.001 μm particles, believed to be the hydroxide. These particles are neither dissolved nor is 244Cm chelated by the trisodium calcium and zinc salts of diethylenetriaminepentaacetic acid (DTPA) when the compounds are administered at therapeutic levels. By inhibiting the reaction between the particles and serum proteins in the blood, however, DTPA permits the rapid dialysis of the particles into the urine. This process is so efficient that the deposition of 244Cm in extrapulmonary tissue can be reduced to trivial amounts by administering Na3ZnDTPA at concentrations appreciably below the currently recommended level.
|Number of pages||9|
|Journal||International Journal of Nuclear Medicine and Biology|
|Publication status||Published - 1979|