The use of DTPA for removing extrapulmonary curium-244 from the rat

G. N. Stradling; John Cooper; H. Smith; S. E. Ham

doi:10.1016/0047-0740(79)90037-8

The use of DTPA for removing extrapulmonary curium-244 from the rat

G. N. Stradling^*, John Cooper, H. Smith, S. E. Ham

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Following the uptake of curium-244 dioxide, a major factor influencing the movement of ²⁴⁴Cm from lungs to blood and urine is the formation and transport of 0.001 μm particles, believed to be the hydroxide. These particles are neither dissolved nor is ²⁴⁴Cm chelated by the trisodium calcium and zinc salts of diethylenetriaminepentaacetic acid (DTPA) when the compounds are administered at therapeutic levels. By inhibiting the reaction between the particles and serum proteins in the blood, however, DTPA permits the rapid dialysis of the particles into the urine. This process is so efficient that the deposition of ²⁴⁴Cm in extrapulmonary tissue can be reduced to trivial amounts by administering Na₃ZnDTPA at concentrations appreciably below the currently recommended level.

Original language	English
Pages (from-to)	183-191
Number of pages	9
Journal	International Journal of Nuclear Medicine and Biology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0047-0740(79)90037-8
Publication status	Published - 1979

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title = "The use of DTPA for removing extrapulmonary curium-244 from the rat",

abstract = "Following the uptake of curium-244 dioxide, a major factor influencing the movement of 244Cm from lungs to blood and urine is the formation and transport of 0.001 μm particles, believed to be the hydroxide. These particles are neither dissolved nor is 244Cm chelated by the trisodium calcium and zinc salts of diethylenetriaminepentaacetic acid (DTPA) when the compounds are administered at therapeutic levels. By inhibiting the reaction between the particles and serum proteins in the blood, however, DTPA permits the rapid dialysis of the particles into the urine. This process is so efficient that the deposition of 244Cm in extrapulmonary tissue can be reduced to trivial amounts by administering Na3ZnDTPA at concentrations appreciably below the currently recommended level.",

author = "Stradling, {G. N.} and John Cooper and H. Smith and Ham, {S. E.}",

year = "1979",

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AU - Stradling, G. N.

AU - Cooper, John

AU - Smith, H.

AU - Ham, S. E.

PY - 1979

Y1 - 1979

N2 - Following the uptake of curium-244 dioxide, a major factor influencing the movement of 244Cm from lungs to blood and urine is the formation and transport of 0.001 μm particles, believed to be the hydroxide. These particles are neither dissolved nor is 244Cm chelated by the trisodium calcium and zinc salts of diethylenetriaminepentaacetic acid (DTPA) when the compounds are administered at therapeutic levels. By inhibiting the reaction between the particles and serum proteins in the blood, however, DTPA permits the rapid dialysis of the particles into the urine. This process is so efficient that the deposition of 244Cm in extrapulmonary tissue can be reduced to trivial amounts by administering Na3ZnDTPA at concentrations appreciably below the currently recommended level.

AB - Following the uptake of curium-244 dioxide, a major factor influencing the movement of 244Cm from lungs to blood and urine is the formation and transport of 0.001 μm particles, believed to be the hydroxide. These particles are neither dissolved nor is 244Cm chelated by the trisodium calcium and zinc salts of diethylenetriaminepentaacetic acid (DTPA) when the compounds are administered at therapeutic levels. By inhibiting the reaction between the particles and serum proteins in the blood, however, DTPA permits the rapid dialysis of the particles into the urine. This process is so efficient that the deposition of 244Cm in extrapulmonary tissue can be reduced to trivial amounts by administering Na3ZnDTPA at concentrations appreciably below the currently recommended level.

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SN - 0047-0740

VL - 6

SP - 183

EP - 191

JO - International Journal of Nuclear Medicine and Biology

JF - International Journal of Nuclear Medicine and Biology

IS - 4

ER -

The use of DTPA for removing extrapulmonary curium-244 from the rat

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