The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

Jane Turton; M. Elaina Ward; Neil Woodford; Mary E. Kaufmann; Rachel Pike; David M. Livermore; Tyrone L. Pitt

doi:10.1111/j.1574-6968.2006.00195.x

The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

Jane Turton^*, M. Elaina Ward, Neil Woodford, Mary E. Kaufmann, Rachel Pike, David M. Livermore, Tyrone L. Pitt

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

661 Citations (Scopus)

Abstract

ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a bla_OXA-51-like carbapenemase gene; some also had bla_OXA-23-like and/or bla _OXA-58-like. Among isolates with bla_OXA-51-like as sole carbapenemase gene, only those with ISAba1 adjacent to bla_OXA-51-like were carbapenem resistant. Minor differences in bla_OXA-51-like sequence were observed in resistant and susceptible isolates. Isolates with bla_OXA-23-like in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of bla_OXA-23-like, but was not associated with bla_OXA-51-like. These results suggest that ISAba1 is providing the promoter for bla_OXA-51-like and, probably, for bla_OXA-23-like.

Original language	English
Pages (from-to)	72-77
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	258
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2006.00195.x
Publication status	Published - May 2006

Keywords

Acinetobacter baumannii
Insertion sequence
OXA carbapenemase

Access to Document

10.1111/j.1574-6968.2006.00195.x

Cite this

@article{c85125bfb44d4f4cb32d544628c601f5,

title = "The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii",

abstract = "ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/or bla OXA-58-like. Among isolates with blaOXA-51-like as sole carbapenemase gene, only those with ISAba1 adjacent to blaOXA-51-like were carbapenem resistant. Minor differences in blaOXA-51-like sequence were observed in resistant and susceptible isolates. Isolates with blaOXA-23-like in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of blaOXA-23-like, but was not associated with blaOXA-51-like. These results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blaOXA-23-like.",

keywords = "Acinetobacter baumannii, Insertion sequence, OXA carbapenemase",

author = "Jane Turton and Ward, \{M. Elaina\} and Neil Woodford and Kaufmann, \{Mary E.\} and Rachel Pike and Livermore, \{David M.\} and Pitt, \{Tyrone L.\}",

year = "2006",

month = may,

doi = "10.1111/j.1574-6968.2006.00195.x",

language = "English",

volume = "258",

pages = "72--77",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

AU - Turton, Jane

AU - Ward, M. Elaina

AU - Woodford, Neil

AU - Kaufmann, Mary E.

AU - Pike, Rachel

AU - Livermore, David M.

AU - Pitt, Tyrone L.

PY - 2006/5

Y1 - 2006/5

N2 - ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/or bla OXA-58-like. Among isolates with blaOXA-51-like as sole carbapenemase gene, only those with ISAba1 adjacent to blaOXA-51-like were carbapenem resistant. Minor differences in blaOXA-51-like sequence were observed in resistant and susceptible isolates. Isolates with blaOXA-23-like in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of blaOXA-23-like, but was not associated with blaOXA-51-like. These results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blaOXA-23-like.

AB - ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/or bla OXA-58-like. Among isolates with blaOXA-51-like as sole carbapenemase gene, only those with ISAba1 adjacent to blaOXA-51-like were carbapenem resistant. Minor differences in blaOXA-51-like sequence were observed in resistant and susceptible isolates. Isolates with blaOXA-23-like in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of blaOXA-23-like, but was not associated with blaOXA-51-like. These results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blaOXA-23-like.

KW - Acinetobacter baumannii

KW - Insertion sequence

KW - OXA carbapenemase

UR - https://www.scopus.com/pages/publications/33645471162

U2 - 10.1111/j.1574-6968.2006.00195.x

DO - 10.1111/j.1574-6968.2006.00195.x

M3 - Article

C2 - 16630258

AN - SCOPUS:33645471162

SN - 0378-1097

VL - 258

SP - 72

EP - 77

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

ER -

The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this