The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection

J. W. Stather; H. Smith; Michael Bailey; A. Birchall; Robert Bulman; F. E.H. Crawley

doi:10.1097/00004032-198301000-00006

The retention of ¹⁴C-DTPA in human volunteers after inhalation or intravenous injection

J. W. Stather, H. Smith, Michael Bailey, A. Birchall, Robert Bulman, F. E.H. Crawley

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Abstract

This study in human volunteers was designed to compare the retention of diethylenetriaminepentaacetic acid (DTPA) in the body after intravenous (i.v.) injection with that following inhalation by using a ¹⁴C labelled tracer. After i.v. Injection retention in the blood could be described by three exponential components with half-times of about 1.4 min (~60%) 14.3 min (~20%) and 95 min (~20%). By 24 hr more than 99% of the ¹⁴C-DTPA had been excreted in the urine and less than 0.5% remained in the plasma. After inhalation of ¹⁴C-DTPA retention in the lungs could be represented by a single component with a half time of about 75 min. As a consequence the length of time that a therapeutically useful amount of DTPA is retained in the body is approximately twice that following intravenous injection.

Original language	English
Pages (from-to)	45-52
Number of pages	8
Journal	Health Physics
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/00004032-198301000-00006
Publication status	Published - Jan 1983

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title = "The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection",

abstract = "This study in human volunteers was designed to compare the retention of diethylenetriaminepentaacetic acid (DTPA) in the body after intravenous (i.v.) injection with that following inhalation by using a 14C labelled tracer. After i.v. Injection retention in the blood could be described by three exponential components with half-times of about 1.4 min (~60%) 14.3 min (~20%) and 95 min (~20%). By 24 hr more than 99% of the 14C-DTPA had been excreted in the urine and less than 0.5% remained in the plasma. After inhalation of 14C-DTPA retention in the lungs could be represented by a single component with a half time of about 75 min. As a consequence the length of time that a therapeutically useful amount of DTPA is retained in the body is approximately twice that following intravenous injection.",

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AU - Bulman, Robert

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AB - This study in human volunteers was designed to compare the retention of diethylenetriaminepentaacetic acid (DTPA) in the body after intravenous (i.v.) injection with that following inhalation by using a 14C labelled tracer. After i.v. Injection retention in the blood could be described by three exponential components with half-times of about 1.4 min (~60%) 14.3 min (~20%) and 95 min (~20%). By 24 hr more than 99% of the 14C-DTPA had been excreted in the urine and less than 0.5% remained in the plasma. After inhalation of 14C-DTPA retention in the lungs could be represented by a single component with a half time of about 75 min. As a consequence the length of time that a therapeutically useful amount of DTPA is retained in the body is approximately twice that following intravenous injection.

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The retention of ¹⁴C-DTPA in human volunteers after inhalation or intravenous injection

Abstract

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