The repair of γ-ray-induced chromosomal damage in human lymphocytes after exposure to extremely low frequency electromagnetic fields

D. Lloyd; P. Hone; Alan Edwards; R. Cox; J. Halls

doi:10.1159/000077487

The repair of γ-ray-induced chromosomal damage in human lymphocytes after exposure to extremely low frequency electromagnetic fields

D. Lloyd^*, P. Hone, Alan Edwards, R. Cox, J. Halls

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

G₀ human blood lymphocytes were irradiated with 2.0 Gy γ-rays and cultured to metaphase whilst held in a 50-Hz power frequency magnetic field of 0.23, 0.47 or 0.7 mT. No differences were found in the frequencies of γ-induced chromosome aberrations observed in cells held in the EM fields compared with replicates held in a sham coil. Similar field conditions have been reported to increase the frequency of γ-induced HPRT mutations, leading to a suggestion that the EM fields alter the fidelity of repair of genomic lesions. This was not confirmed by the chromosome aberration assay described here.

Original language	English
Pages (from-to)	188-192
Number of pages	5
Journal	Cytogenetic and Genome Research
Volume	104
Issue number	1-4
DOIs	https://doi.org/10.1159/000077487
Publication status	Published - 2004

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abstract = "G0 human blood lymphocytes were irradiated with 2.0 Gy γ-rays and cultured to metaphase whilst held in a 50-Hz power frequency magnetic field of 0.23, 0.47 or 0.7 mT. No differences were found in the frequencies of γ-induced chromosome aberrations observed in cells held in the EM fields compared with replicates held in a sham coil. Similar field conditions have been reported to increase the frequency of γ-induced HPRT mutations, leading to a suggestion that the EM fields alter the fidelity of repair of genomic lesions. This was not confirmed by the chromosome aberration assay described here.",

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AU - Lloyd, D.

AU - Hone, P.

AU - Edwards, Alan

AU - Cox, R.

AU - Halls, J.

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AB - G0 human blood lymphocytes were irradiated with 2.0 Gy γ-rays and cultured to metaphase whilst held in a 50-Hz power frequency magnetic field of 0.23, 0.47 or 0.7 mT. No differences were found in the frequencies of γ-induced chromosome aberrations observed in cells held in the EM fields compared with replicates held in a sham coil. Similar field conditions have been reported to increase the frequency of γ-induced HPRT mutations, leading to a suggestion that the EM fields alter the fidelity of repair of genomic lesions. This was not confirmed by the chromosome aberration assay described here.

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The repair of γ-ray-induced chromosomal damage in human lymphocytes after exposure to extremely low frequency electromagnetic fields

Abstract

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