The reactions of 1·0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid

John Cooper; G. N. Stradling; H. Smith; S. E. Breadmore

doi:10.1080/09553007914551251

The reactions of 1·0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid

John Cooper^*, G. N. Stradling, H. Smith, S. E. Breadmore

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The reactions of 1·0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography. The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate.

Original language	English
Pages (from-to)	453-466
Number of pages	14
Journal	International Journal of Radiation Biology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1080/09553007914551251
Publication status	Published - 1979

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10.1080/09553007914551251

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title = "The reactions of 1·0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid",

abstract = "The reactions of 1·0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography. The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate.",

author = "John Cooper and Stradling, {G. N.} and H. Smith and Breadmore, {S. E.}",

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AU - Breadmore, S. E.

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N2 - The reactions of 1·0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography. The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate.

AB - The reactions of 1·0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography. The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate.

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The reactions of 1·0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid

Abstract

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