The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure

G. N. Stradling*, J. W. Stather, S. A. Gray, J. C. Moody, A. Hodgson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This paper describes the metabolic behaviour in rats of uranium inhaled as a U3O8 bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 × 103 Bq) whilst urinary excretion data should be interpreted with caution.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalExperimental Pathology
Volume37
Issue number1-4
DOIs
Publication statusPublished - 1989

Bibliographical note

Funding Information:
This paper is based on work supported by the Procurement Executive, Ministry of Defence. The authors thank Ms. K. WOOD for animal care.

Keywords

  • chest monitoring
  • intake, limit
  • occupational exposure
  • uranium octoxide

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