The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure

G. N. Stradling; J. W. Stather; S. A. Gray; J. C. Moody; A. Hodgson

doi:10.1016/S0232-1513(89)80018-0

The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure

G. N. Stradling^*, J. W. Stather, S. A. Gray, J. C. Moody, A. Hodgson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This paper describes the metabolic behaviour in rats of uranium inhaled as a U₃O₈ bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 × 10³ Bq) whilst urinary excretion data should be interpreted with caution.

Original language	English
Pages (from-to)	76-82
Number of pages	7
Journal	Experimental Pathology
Volume	37
Issue number	1-4
DOIs	https://doi.org/10.1016/S0232-1513(89)80018-0
Publication status	Published - 1989

Bibliographical note

Funding Information:
This paper is based on work supported by the Procurement Executive, Ministry of Defence. The authors thank Ms. K. WOOD for animal care.

Keywords

chest monitoring
intake, limit
occupational exposure
uranium octoxide

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10.1016/S0232-1513(89)80018-0

Cite this

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title = "The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure",

abstract = "This paper describes the metabolic behaviour in rats of uranium inhaled as a U3O8 bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 × 103 Bq) whilst urinary excretion data should be interpreted with caution.",

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note = "Funding Information: This paper is based on work supported by the Procurement Executive, Ministry of Defence. The authors thank Ms. K. WOOD for animal care.",

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T2 - the implications for occupational exposure

AU - Stradling, G. N.

AU - Stather, J. W.

AU - Gray, S. A.

AU - Moody, J. C.

AU - Hodgson, A.

N1 - Funding Information: This paper is based on work supported by the Procurement Executive, Ministry of Defence. The authors thank Ms. K. WOOD for animal care.

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Y1 - 1989

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AB - This paper describes the metabolic behaviour in rats of uranium inhaled as a U3O8 bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 × 103 Bq) whilst urinary excretion data should be interpreted with caution.

KW - chest monitoring

KW - intake, limit

KW - occupational exposure

KW - uranium octoxide

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JO - Experimental Pathology

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ER -

The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure

Abstract

Bibliographical note

Keywords

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