This paper describes the metabolic behaviour in rats of uranium inhaled as a U3O8 bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 × 103 Bq) whilst urinary excretion data should be interpreted with caution.
Bibliographical noteFunding Information:
This paper is based on work supported by the Procurement Executive, Ministry of Defence. The authors thank Ms. K. WOOD for animal care.
- chest monitoring
- intake, limit
- occupational exposure
- uranium octoxide