The lung clearance kinetics of 57Co3O4 in rats of various ages

C. G. Collier; A. Hodgson; S. A. Gray; J. C. Moody; A. Ball

doi:10.1016/0021-8502(91)90009-7

The lung clearance kinetics of ⁵⁷Co₃O₄ in rats of various ages

C. G. Collier^*, A. Hodgson, S. A. Gray, J. C. Moody, A. Ball

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The lung retention of inhaled ⁵⁷Co labelled Co₃O₄ particles was measured in rats whose ages at exposure ranged from 3 to 46 weeks. Significantly lower lung retention was found in the younger animals and this could be attributed to a faster rate of translocation of ⁵Co from the lung to blood. Mechanical clearance rates were similar for all age groups. Comparison of these results with those of other studies suggest that mechanical clearance rates are independent of the chemical form of the material inhaled. The results of this study suggest that in the extrapolation of the results of animal experiments to humans, due consideration should be given to age related changes.

Original language	English
Pages (from-to)	537-549
Number of pages	13
Journal	Journal of Aerosol Science
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0021-8502(91)90009-7
Publication status	Published - 1991

Bibliographical note

Funding Information:
Acknowledgements-- This research ~as partially supported by the CEC under contract number B16-D-089-UK and was coordinated through the European Late Effects Project Task Group on the Interspecles Comparison of Lung Clearance under CEC contract number B16-D-099-D Dr W G Kreyhng, GSF Neuherberg, Mumch, kindly manufactured and supphed the particles

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title = "The lung clearance kinetics of 57Co3O4 in rats of various ages",

abstract = "The lung retention of inhaled 57Co labelled Co3O4 particles was measured in rats whose ages at exposure ranged from 3 to 46 weeks. Significantly lower lung retention was found in the younger animals and this could be attributed to a faster rate of translocation of 5Co from the lung to blood. Mechanical clearance rates were similar for all age groups. Comparison of these results with those of other studies suggest that mechanical clearance rates are independent of the chemical form of the material inhaled. The results of this study suggest that in the extrapolation of the results of animal experiments to humans, due consideration should be given to age related changes.",

author = "Collier, {C. G.} and A. Hodgson and Gray, {S. A.} and Moody, {J. C.} and A. Ball",

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AU - Hodgson, A.

AU - Gray, S. A.

AU - Moody, J. C.

AU - Ball, A.

N1 - Funding Information: Acknowledgements-- This research ~as partially supported by the CEC under contract number B16-D-089-UK and was coordinated through the European Late Effects Project Task Group on the Interspecles Comparison of Lung Clearance under CEC contract number B16-D-099-D Dr W G Kreyhng, GSF Neuherberg, Mumch, kindly manufactured and supphed the particles

PY - 1991

Y1 - 1991

N2 - The lung retention of inhaled 57Co labelled Co3O4 particles was measured in rats whose ages at exposure ranged from 3 to 46 weeks. Significantly lower lung retention was found in the younger animals and this could be attributed to a faster rate of translocation of 5Co from the lung to blood. Mechanical clearance rates were similar for all age groups. Comparison of these results with those of other studies suggest that mechanical clearance rates are independent of the chemical form of the material inhaled. The results of this study suggest that in the extrapolation of the results of animal experiments to humans, due consideration should be given to age related changes.

AB - The lung retention of inhaled 57Co labelled Co3O4 particles was measured in rats whose ages at exposure ranged from 3 to 46 weeks. Significantly lower lung retention was found in the younger animals and this could be attributed to a faster rate of translocation of 5Co from the lung to blood. Mechanical clearance rates were similar for all age groups. Comparison of these results with those of other studies suggest that mechanical clearance rates are independent of the chemical form of the material inhaled. The results of this study suggest that in the extrapolation of the results of animal experiments to humans, due consideration should be given to age related changes.

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JO - Journal of Aerosol Science

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ER -

The lung clearance kinetics of ⁵⁷Co₃O₄ in rats of various ages

Abstract

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