The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure

Dominique Laurier; David B. Richardson; Elisabeth Cardis; Robert D. Daniels; Michael Gillies; Jackie O'Hagan; Ghassan B. Hamra; Richard Haylock; Klervi Leuraud; Monika Moissonnier; Mary K. Schubauer-Berigan; Isabelle Thierry-Chef; Ausrele Kesminiene

doi:10.1093/rpd/ncw314

The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure

Dominique Laurier^*, David B. Richardson, Elisabeth Cardis, Robert D. Daniels, Michael Gillies, Jackie O'Hagan, Ghassan B. Hamra, Richard Haylock, Klervi Leuraud, Monika Moissonnier, Mary K. Schubauer-Berigan, Isabelle Thierry-Chef, Ausrele Kesminiene

^*Corresponding author for this work

Radiation Effects

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Abstract

INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry in France, the United Kingdom and the United States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. Mean individual cumulative external dose over the period 1945-2005 was 25 mSv. Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. INWORKS assembled some of the strongest evidence to strengthen the scientific basis for the protection of adults from low dose, low-dose rate, exposures to ionising radiation.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Radiation Protection Dosimetry
Volume	173
Issue number	1
DOIs	https://doi.org/10.1093/rpd/ncw314
Publication status	Published - 2017

Bibliographical note

Publisher Copyright:
© The Author 2016.

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Laurier, D., Richardson, D. B., Cardis, E., Daniels, R. D., Gillies, M., O'Hagan, J., Hamra, G. B., Haylock, R., Leuraud, K., Moissonnier, M., Schubauer-Berigan, M. K., Thierry-Chef, I., & Kesminiene, A. (2017). The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure. Radiation Protection Dosimetry, 173(1), 21-25. https://doi.org/10.1093/rpd/ncw314

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title = "The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure",

abstract = "INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry in France, the United Kingdom and the United States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. Mean individual cumulative external dose over the period 1945-2005 was 25 mSv. Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. INWORKS assembled some of the strongest evidence to strengthen the scientific basis for the protection of adults from low dose, low-dose rate, exposures to ionising radiation.",

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Laurier, D, Richardson, DB, Cardis, E, Daniels, RD, Gillies, M, O'Hagan, J, Hamra, GB, Haylock, R, Leuraud, K, Moissonnier, M, Schubauer-Berigan, MK, Thierry-Chef, I & Kesminiene, A 2017, 'The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure', Radiation Protection Dosimetry, vol. 173, no. 1, pp. 21-25. https://doi.org/10.1093/rpd/ncw314

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AU - Gillies, Michael

AU - O'Hagan, Jackie

AU - Hamra, Ghassan B.

AU - Haylock, Richard

AU - Leuraud, Klervi

AU - Moissonnier, Monika

AU - Schubauer-Berigan, Mary K.

AU - Thierry-Chef, Isabelle

AU - Kesminiene, Ausrele

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The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure

Abstract

Bibliographical note

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