The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239

A. Bilbao; J. S. Prosser; Alan Edwards; J. C. Moody; D. C. Lloyd

doi:10.1080/09553008914551451

The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239

A. Bilbao^*, J. S. Prosser, Alan Edwards, J. C. Moody, D. C. Lloyd

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3·6 for alpha particles at low doses.

Original language	English
Pages (from-to)	287-292
Number of pages	6
Journal	International Journal of Radiation Biology
Volume	56
Issue number	3
DOIs	https://doi.org/10.1080/09553008914551451
Publication status	Published - 1989

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title = "The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239",

abstract = "Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3·6 for alpha particles at low doses.",

author = "A. Bilbao and Prosser, {J. S.} and Alan Edwards and Moody, {J. C.} and Lloyd, {D. C.}",

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AU - Bilbao, A.

AU - Prosser, J. S.

AU - Edwards, Alan

AU - Moody, J. C.

AU - Lloyd, D. C.

PY - 1989

Y1 - 1989

N2 - Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3·6 for alpha particles at low doses.

AB - Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3·6 for alpha particles at low doses.

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U2 - 10.1080/09553008914551451

DO - 10.1080/09553008914551451

M3 - Article

C2 - 2570814

AN - SCOPUS:0024467628

SN - 0955-3002

VL - 56

SP - 287

EP - 292

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 3

ER -

The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239

Abstract

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