The incubation period of hepatitis e genotype 1: Insights from pooled analyses of travellers

A. S. Azman*, I. Ciglenecki, C. Oeser, B. Said, Richard Tedder, Samreen Ijaz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Hepatitis E virus genotype 1 (HEV G1) is an important cause of morbidity and mortality in Africa and Asia. HEV G1's natural history, including the incubation period, remains poorly understood, hindering surveillance efforts and effective control. Using individual-level data from 85 travel-related HEV G1 cases in England and Wales, we estimate the incubation period distribution using survival analysis methods, which allow for appropriate inference when only time ranges, rather than exact times are known for the exposure to HEV and symptom onset. We estimated a 29.8-day (95% confidence interval (CI) 24.1-36.0) median incubation period with 5% of people expected to develop symptoms within 14.3 days (95% CI 10.1-21.7) and 95% within 61.9 days (95% CI 47.4-74.4) of exposure. These estimates can help refine clinical case definitions and inform the design of disease burden and intervention studies.

Original languageEnglish
Pages (from-to)1533-1536
Number of pages4
JournalEpidemiology and Infection
Issue number12
Publication statusPublished - 1 Sep 2018

Bibliographical note

Publisher Copyright:
Copyright © Cambridge University Press 2018 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.


  • HEV
  • Hepatitis E
  • incubation period
  • survival analysis
  • travellers


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