The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people

David Lloyd; R. J. Purrott; E. J. Reeder

doi:10.1016/0027-5107(80)90123-2

The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people

David Lloyd^*, R. J. Purrott, E. J. Reeder

^*Corresponding author for this work

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199 Citations (Scopus)

Abstract

Peripheral blood lymphocytes from unirradiated control subjects and workers exposed within permitted limits to γ-radiation, have been examined for the incidence of dicentric and acentric chromosome aberrations. The results are compared with a review of data published elsewhere. Background levels show inter-laboratory variation and possible reasons for this are discussed. By combining the present data with those from the literature the spontaneous incidence of dicentric aberrations is approx. 0.55 × 10⁻³ and for acentrics is 3.7 × 10⁻³. In occupationally exposed subjects a significantly higher incidence of aberrations was found. When allowance was made for the turnover of lymphocytes for the period over which each man had worked with radiation a linear dose-effect relationship was apparent. The incidence of dicentrics was 2.22 ± 0.94 × 10⁻⁴ rad⁻¹ and for all unstable aberrations 8.24 ± 2.8 × 10⁻⁴ rad⁻¹. These are in reasonable agreement with dose-response data obtained in vitro.

Original language	English
Pages (from-to)	523-532
Number of pages	10
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0027-5107(80)90123-2
Publication status	Published - 1980

Bibliographical note

Funding Information:
The authors wish to thank the workers and medical staff for providing blood samples and dose records, Dawn Bolton, Liz Hesketh and Susan Priseman for contributing to the microscope scoring and Mr. A. Edwards for advice on statistics. The work was partly supported by Euratom Contract 171-76-1 BIO UK.

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title = "The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people",

abstract = "Peripheral blood lymphocytes from unirradiated control subjects and workers exposed within permitted limits to γ-radiation, have been examined for the incidence of dicentric and acentric chromosome aberrations. The results are compared with a review of data published elsewhere. Background levels show inter-laboratory variation and possible reasons for this are discussed. By combining the present data with those from the literature the spontaneous incidence of dicentric aberrations is approx. 0.55 × 10−3 and for acentrics is 3.7 × 10−3. In occupationally exposed subjects a significantly higher incidence of aberrations was found. When allowance was made for the turnover of lymphocytes for the period over which each man had worked with radiation a linear dose-effect relationship was apparent. The incidence of dicentrics was 2.22 ± 0.94 × 10−4 rad−1 and for all unstable aberrations 8.24 ± 2.8 × 10−4 rad−1. These are in reasonable agreement with dose-response data obtained in vitro.",

author = "David Lloyd and Purrott, {R. J.} and Reeder, {E. J.}",

note = "Funding Information: The authors wish to thank the workers and medical staff for providing blood samples and dose records, Dawn Bolton, Liz Hesketh and Susan Priseman for contributing to the microscope scoring and Mr. A. Edwards for advice on statistics. The work was partly supported by Euratom Contract 171-76-1 BIO UK.",

year = "1980",

doi = "10.1016/0027-5107(80)90123-2",

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AU - Lloyd, David

AU - Purrott, R. J.

AU - Reeder, E. J.

N1 - Funding Information: The authors wish to thank the workers and medical staff for providing blood samples and dose records, Dawn Bolton, Liz Hesketh and Susan Priseman for contributing to the microscope scoring and Mr. A. Edwards for advice on statistics. The work was partly supported by Euratom Contract 171-76-1 BIO UK.

PY - 1980

Y1 - 1980

N2 - Peripheral blood lymphocytes from unirradiated control subjects and workers exposed within permitted limits to γ-radiation, have been examined for the incidence of dicentric and acentric chromosome aberrations. The results are compared with a review of data published elsewhere. Background levels show inter-laboratory variation and possible reasons for this are discussed. By combining the present data with those from the literature the spontaneous incidence of dicentric aberrations is approx. 0.55 × 10−3 and for acentrics is 3.7 × 10−3. In occupationally exposed subjects a significantly higher incidence of aberrations was found. When allowance was made for the turnover of lymphocytes for the period over which each man had worked with radiation a linear dose-effect relationship was apparent. The incidence of dicentrics was 2.22 ± 0.94 × 10−4 rad−1 and for all unstable aberrations 8.24 ± 2.8 × 10−4 rad−1. These are in reasonable agreement with dose-response data obtained in vitro.

AB - Peripheral blood lymphocytes from unirradiated control subjects and workers exposed within permitted limits to γ-radiation, have been examined for the incidence of dicentric and acentric chromosome aberrations. The results are compared with a review of data published elsewhere. Background levels show inter-laboratory variation and possible reasons for this are discussed. By combining the present data with those from the literature the spontaneous incidence of dicentric aberrations is approx. 0.55 × 10−3 and for acentrics is 3.7 × 10−3. In occupationally exposed subjects a significantly higher incidence of aberrations was found. When allowance was made for the turnover of lymphocytes for the period over which each man had worked with radiation a linear dose-effect relationship was apparent. The incidence of dicentrics was 2.22 ± 0.94 × 10−4 rad−1 and for all unstable aberrations 8.24 ± 2.8 × 10−4 rad−1. These are in reasonable agreement with dose-response data obtained in vitro.

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ER -

The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people

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