Peripheral blood lymphocytes from unirradiated control subjects and workers exposed within permitted limits to γ-radiation, have been examined for the incidence of dicentric and acentric chromosome aberrations. The results are compared with a review of data published elsewhere. Background levels show inter-laboratory variation and possible reasons for this are discussed. By combining the present data with those from the literature the spontaneous incidence of dicentric aberrations is approx. 0.55 × 10−3 and for acentrics is 3.7 × 10−3. In occupationally exposed subjects a significantly higher incidence of aberrations was found. When allowance was made for the turnover of lymphocytes for the period over which each man had worked with radiation a linear dose-effect relationship was apparent. The incidence of dicentrics was 2.22 ± 0.94 × 10−4 rad−1 and for all unstable aberrations 8.24 ± 2.8 × 10−4 rad−1. These are in reasonable agreement with dose-response data obtained in vitro.
|Number of pages||10|
|Journal||Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis|
|Publication status||Published - 1980|
Bibliographical noteFunding Information:
The authors wish to thank the workers and medical staff for providing blood samples and dose records, Dawn Bolton, Liz Hesketh and Susan Priseman for contributing to the microscope scoring and Mr. A. Edwards for advice on statistics. The work was partly supported by Euratom Contract 171-76-1 BIO UK.