The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices

Tiina Santonen; Henriqueta Louro; Beatrice Bocca; Radia Bousoumah; Radu Corneliu Duca; Aleksandra Fucic; Karen S. Galea; Lode Godderis; Thomas Göen; Ivo Iavicoli; Beata Janasik; Kate Jones; Elizabeth Leese; Veruscka Leso; Sophie Ndaw; Katrien Poels; Simo P. Porras; Flavia Ruggieri; Maria J. Silva; An Van Nieuwenhuyse; Jelle Verdonck; Wojciech Wasowicz; Ana Tavares; Ovnair Sepai; Paul T.J. Scheepers; Susana Viegas

doi:10.1016/j.ijheh.2022.114099

The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices

Tiina Santonen^*, Henriqueta Louro, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Aleksandra Fucic, Karen S. Galea, Lode Godderis, Thomas Göen, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria J. Silva, An Van NieuwenhuyseJelle Verdonck, Wojciech Wasowicz, Ana Tavares, Ovnair Sepai, Paul T.J. Scheepers, Susana Viegas

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Within the EU human biomonitoring initiative (HBM4EU), a targeted, multi-national study on occupational exposure to hexavalent chromium (Cr(VI)) was performed. Cr(VI) is currently regulated in EU under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and under occupational safety and health (OSH) legislation. It has recently been subject to regulatory actions to improve its risk management in European workplaces. Analysis of the data obtained within the HBM4EU chromates study provides support both for the implementation of these regulatory actions and for national enforcement programs and may also contribute to the updating of occupational limit values (OELs) and biological limit values for Cr(VI). It also provides useful insights on the contribution of different risk management measures (RMMs) to further reduce the exposure to Cr(VI) and may support the evaluation of applications for authorisation under REACH. Findings on chrome platers’ additional per- and polyfluoroalkyl substances (PFAS) exposure highlight the need to also pay attention to this substance group in the metals sector. A survey performed to evaluate the policy relevance of the HBM4EU chromates study findings supports the usefulness of the study results. According to the responses received from the survey, the HBM4EU chromates study was able to demonstrate the added value of the human biomonitoring (HBM) approach in assessment and management of occupational exposure to Cr(VI). For future occupational studies, we emphasise the need for engagement of policy makers and regulators throughout the whole research process to ensure awareness, relevance and uptake of the results in future policies.

Original language	English
Article number	114099
Journal	International Journal of Hygiene and Environmental Health
Volume	248
Early online date	17 Dec 2022
DOIs	https://doi.org/10.1016/j.ijheh.2022.114099
Publication status	Published - Mar 2023

Bibliographical note

Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries.

Open Access: This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

Publisher Copyright: © 2022 The Authors. Published by Elsevier GmbH.

Citation: Tiina Santonen, Henriqueta Louro, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Aleksandra Fucic, Karen S. Galea, Lode Godderis, Thomas Göen, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria J. Silva, An Van Nieuwenhuyse, Jelle Verdonck, Wojciech Wasowicz, Ana Tavares, Ovnair Sepai, Paul T.J. Scheepers, Susana Viegas, The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices, International Journal of Hygiene and Environmental Health, Volume 248, 2023, 114099, ISSN 1438-4639, https://doi.org/10.1016/j.ijheh.2022.114099.

DOI: https://doi.org/10.1016/j.ijheh.2022.114099.

Keywords

Biomonitoring
Carcinogens, mutagens and reprotoxic substances directive
EU
HBM4EU
Hexavalent chromium
Occupational exposure limit values
REACH

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Santonen2023TheHBM4EUChromatesStudyOutcomesAndImpactsOnEUPoliciesAndOccupationalHealthPracticesIntJHygEnvironHealthFinal published version, 1.61 MBLicence: CC BY-NC-ND

Cite this

Santonen, T., Louro, H., Bocca, B., Bousoumah, R., Duca, R. C., Fucic, A., Galea, K. S., Godderis, L., Göen, T., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Ndaw, S., Poels, K., Porras, S. P., Ruggieri, F., Silva, M. J., ... Viegas, S. (2023). The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices. International Journal of Hygiene and Environmental Health, 248, Article 114099. https://doi.org/10.1016/j.ijheh.2022.114099

@article{afb5f72c7513493693b87e5b2905d17a,

title = "The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices",

abstract = "Within the EU human biomonitoring initiative (HBM4EU), a targeted, multi-national study on occupational exposure to hexavalent chromium (Cr(VI)) was performed. Cr(VI) is currently regulated in EU under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and under occupational safety and health (OSH) legislation. It has recently been subject to regulatory actions to improve its risk management in European workplaces. Analysis of the data obtained within the HBM4EU chromates study provides support both for the implementation of these regulatory actions and for national enforcement programs and may also contribute to the updating of occupational limit values (OELs) and biological limit values for Cr(VI). It also provides useful insights on the contribution of different risk management measures (RMMs) to further reduce the exposure to Cr(VI) and may support the evaluation of applications for authorisation under REACH. Findings on chrome platers{\textquoteright} additional per- and polyfluoroalkyl substances (PFAS) exposure highlight the need to also pay attention to this substance group in the metals sector. A survey performed to evaluate the policy relevance of the HBM4EU chromates study findings supports the usefulness of the study results. According to the responses received from the survey, the HBM4EU chromates study was able to demonstrate the added value of the human biomonitoring (HBM) approach in assessment and management of occupational exposure to Cr(VI). For future occupational studies, we emphasise the need for engagement of policy makers and regulators throughout the whole research process to ensure awareness, relevance and uptake of the results in future policies.",

keywords = "Biomonitoring, Carcinogens, mutagens and reprotoxic substances directive, EU, HBM4EU, Hexavalent chromium, Occupational exposure limit values, REACH",

author = "Tiina Santonen and Henriqueta Louro and Beatrice Bocca and Radia Bousoumah and Duca, {Radu Corneliu} and Aleksandra Fucic and Galea, {Karen S.} and Lode Godderis and Thomas G{\"o}en and Ivo Iavicoli and Beata Janasik and Kate Jones and Elizabeth Leese and Veruscka Leso and Sophie Ndaw and Katrien Poels and Porras, {Simo P.} and Flavia Ruggieri and Silva, {Maria J.} and {Van Nieuwenhuyse}, An and Jelle Verdonck and Wojciech Wasowicz and Ana Tavares and Ovnair Sepai and Scheepers, {Paul T.J.} and Susana Viegas",

note = "Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author{\textquoteright}s organizations and/or Ministries. Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Publisher Copyright: {\textcopyright} 2022 The Authors. Published by Elsevier GmbH. Citation: Tiina Santonen, Henriqueta Louro, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Aleksandra Fucic, Karen S. Galea, Lode Godderis, Thomas G{\"o}en, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria J. Silva, An Van Nieuwenhuyse, Jelle Verdonck, Wojciech Wasowicz, Ana Tavares, Ovnair Sepai, Paul T.J. Scheepers, Susana Viegas, The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices, International Journal of Hygiene and Environmental Health, Volume 248, 2023, 114099, ISSN 1438-4639, https://doi.org/10.1016/j.ijheh.2022.114099. DOI: https://doi.org/10.1016/j.ijheh.2022.114099.",

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Santonen, T, Louro, H, Bocca, B, Bousoumah, R, Duca, RC, Fucic, A, Galea, KS, Godderis, L, Göen, T, Iavicoli, I, Janasik, B, Jones, K, Leese, E, Leso, V, Ndaw, S, Poels, K, Porras, SP, Ruggieri, F, Silva, MJ, Van Nieuwenhuyse, A, Verdonck, J, Wasowicz, W, Tavares, A, Sepai, O, Scheepers, PTJ & Viegas, S 2023, 'The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices', International Journal of Hygiene and Environmental Health, vol. 248, 114099. https://doi.org/10.1016/j.ijheh.2022.114099

TY - JOUR

T1 - The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices

AU - Santonen, Tiina

AU - Louro, Henriqueta

AU - Bocca, Beatrice

AU - Bousoumah, Radia

AU - Duca, Radu Corneliu

AU - Fucic, Aleksandra

AU - Galea, Karen S.

AU - Godderis, Lode

AU - Göen, Thomas

AU - Iavicoli, Ivo

AU - Janasik, Beata

AU - Jones, Kate

AU - Leese, Elizabeth

AU - Leso, Veruscka

AU - Ndaw, Sophie

AU - Poels, Katrien

AU - Porras, Simo P.

AU - Ruggieri, Flavia

AU - Silva, Maria J.

AU - Van Nieuwenhuyse, An

AU - Verdonck, Jelle

AU - Wasowicz, Wojciech

AU - Tavares, Ana

AU - Sepai, Ovnair

AU - Scheepers, Paul T.J.

AU - Viegas, Susana

N1 - Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries. Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Publisher Copyright: © 2022 The Authors. Published by Elsevier GmbH. Citation: Tiina Santonen, Henriqueta Louro, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Aleksandra Fucic, Karen S. Galea, Lode Godderis, Thomas Göen, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria J. Silva, An Van Nieuwenhuyse, Jelle Verdonck, Wojciech Wasowicz, Ana Tavares, Ovnair Sepai, Paul T.J. Scheepers, Susana Viegas, The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices, International Journal of Hygiene and Environmental Health, Volume 248, 2023, 114099, ISSN 1438-4639, https://doi.org/10.1016/j.ijheh.2022.114099. DOI: https://doi.org/10.1016/j.ijheh.2022.114099.

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Y1 - 2023/3

N2 - Within the EU human biomonitoring initiative (HBM4EU), a targeted, multi-national study on occupational exposure to hexavalent chromium (Cr(VI)) was performed. Cr(VI) is currently regulated in EU under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and under occupational safety and health (OSH) legislation. It has recently been subject to regulatory actions to improve its risk management in European workplaces. Analysis of the data obtained within the HBM4EU chromates study provides support both for the implementation of these regulatory actions and for national enforcement programs and may also contribute to the updating of occupational limit values (OELs) and biological limit values for Cr(VI). It also provides useful insights on the contribution of different risk management measures (RMMs) to further reduce the exposure to Cr(VI) and may support the evaluation of applications for authorisation under REACH. Findings on chrome platers’ additional per- and polyfluoroalkyl substances (PFAS) exposure highlight the need to also pay attention to this substance group in the metals sector. A survey performed to evaluate the policy relevance of the HBM4EU chromates study findings supports the usefulness of the study results. According to the responses received from the survey, the HBM4EU chromates study was able to demonstrate the added value of the human biomonitoring (HBM) approach in assessment and management of occupational exposure to Cr(VI). For future occupational studies, we emphasise the need for engagement of policy makers and regulators throughout the whole research process to ensure awareness, relevance and uptake of the results in future policies.

AB - Within the EU human biomonitoring initiative (HBM4EU), a targeted, multi-national study on occupational exposure to hexavalent chromium (Cr(VI)) was performed. Cr(VI) is currently regulated in EU under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and under occupational safety and health (OSH) legislation. It has recently been subject to regulatory actions to improve its risk management in European workplaces. Analysis of the data obtained within the HBM4EU chromates study provides support both for the implementation of these regulatory actions and for national enforcement programs and may also contribute to the updating of occupational limit values (OELs) and biological limit values for Cr(VI). It also provides useful insights on the contribution of different risk management measures (RMMs) to further reduce the exposure to Cr(VI) and may support the evaluation of applications for authorisation under REACH. Findings on chrome platers’ additional per- and polyfluoroalkyl substances (PFAS) exposure highlight the need to also pay attention to this substance group in the metals sector. A survey performed to evaluate the policy relevance of the HBM4EU chromates study findings supports the usefulness of the study results. According to the responses received from the survey, the HBM4EU chromates study was able to demonstrate the added value of the human biomonitoring (HBM) approach in assessment and management of occupational exposure to Cr(VI). For future occupational studies, we emphasise the need for engagement of policy makers and regulators throughout the whole research process to ensure awareness, relevance and uptake of the results in future policies.

KW - Biomonitoring

KW - Carcinogens, mutagens and reprotoxic substances directive

KW - EU

KW - HBM4EU

KW - Hexavalent chromium

KW - Occupational exposure limit values

KW - REACH

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DO - 10.1016/j.ijheh.2022.114099

M3 - Review article

AN - SCOPUS:85144410583

SN - 1438-4639

VL - 248

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

M1 - 114099

ER -

The HBM4EU chromates study – Outcomes and impacts on EU policies and occupational health practices

Abstract

Bibliographical note

Keywords

UN SDGs

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