The future trajectory of adverse outcome pathways: a commentary

Fiona Sewell*, Nichola Gellatly, Maria Beaumont, Natalie Burden, Richard Currie, Lolke de Haan, Thomas H. Hutchinson, Miriam Jacobs, Catherine Mahony, Ian Malcomber, Jyotigna Mehta, Graham Whale, Ian Kimber

*Corresponding author for this work

Research output: Contribution to journalEditorial

16 Citations (Scopus)


The advent of adverse outcome pathways (AOPs) has provided a new lexicon for description of mechanistic toxicology, and a renewed enthusiasm for exploring modes of action resulting in adverse health and environmental effects. In addition, AOPs have been used successfully as a framework for the design and development of non-animal approaches to toxicity testing. Although the value of AOPs is widely recognised, there remain challenges and opportunities associated with their use in practise. The purpose of this article is to consider specifically how the future trajectory of AOPs may provide a basis for addressing some of those challenges and opportunities.

Original languageEnglish
Pages (from-to)1657-1661
Number of pages5
JournalArchives of Toxicology
Issue number4
Publication statusPublished - 1 Apr 2018

Bibliographical note

Publisher Copyright:
© 2018, The Author(s).


  • Adverse outcome pathways (AOPs)
  • Hazard identification
  • Risk assessment
  • Safety assessment


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