The epidemiology of herpes zoster and potential cost-effectiveness of vaccination in England and Wales

William Edmunds*, M. Brisson, J. D. Rose

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

170 Citations (Scopus)

Abstract

The epidemiology of herpes zoster and post-herpetic neuralgia (PHN) was quantified from a variety of data sources and the potential cost-effectiveness of vaccination assessed. The annual incidence and severity of zoster increases sharply with age, as measured by physician consultation and hospitalisation rates, average length of stay, average proportion of cases developing PHN and the age-specific case-fatality ratio. Combining these data with information on health related quality of life results in an estimated loss of 20 000 quality adjusted life years (QALYs) annually in England and Wales from herpes zoster (17 400 due to PHN). The current cost of treating herpes zoster associated disease is estimated to be £47.6m annually. Since both the health and economic burden are high, vaccination of the elderly is expected to be cost-effective under most scenarios, the attractiveness of immunisation increasing with age due to the increased burden of disease in the very elderly.

Original languageEnglish
Pages (from-to)3076-3090
Number of pages15
JournalVaccine
Volume19
Issue number23-24
DOIs
Publication statusPublished - 30 Apr 2001

Bibliographical note

Funding Information:
The United Kingdom Medical Research Council, Grant number G9818303, provided financial support. We thank Dr Elizabeth Miller for comments on the manuscript and Usha Gungabissoon for obtaining the mortality data.

Keywords

  • Cost-effectiveness analysis
  • Herpes zoster
  • Vaccination

Fingerprint

Dive into the research topics of 'The epidemiology of herpes zoster and potential cost-effectiveness of vaccination in England and Wales'. Together they form a unique fingerprint.

Cite this