The epidemiology and management of clusters of invasive meningococcal disease in England, 2010-15

Maya Gobin, Gareth Hughes, Sarah Foulkes, Helen Bagnall, Amy Trindall, Valérie Decraene, Obaghe Edeghere, Sooria Balasegaram, Amelia Cummins, Louise Coole*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Guidance for public health management of invasive meningococcal disease (IMD) in in England recommends the use of antibiotic chemoprophylaxis and vaccination. We summarized clinical and epidemiological data collected during routine management of IMD clusters in England. Methods: Data on epidemiology and operational decisions for public health management were reviewed for clusters between April 2010 and December 2015. Results: Clusters were generally 2-3 cases (53/58; 91%) within a single age band <18-years. Nurseries (n = 20, 34%), households/social networks (n = 14, 24%) and schools (n = 10, 17%) were the commonest settings. Chemoprophylaxis alone was used in 36 (58%) clusters, including most serogroup B clusters (31/41; 76%). Chemoprophylaxis and vaccination was used in a further 20 (32%) clusters. Vaccine was delivered promptly (<7 days). Four clusters had cases with onset post-chemoprophylaxis; no clusters recorded cases with onset post-vaccination. No pattern was observed between interventions and setting/population at risk, and interventions were consistent with national guidance. Challenges to management included logistical issues related to intervention delivery. Conclusions: Public health management of IMD clusters presents challenges in decision-making and implementation of interventions. Nonetheless, few cases were observed following intervention. Responses were consistent with national guidance. A systematic data collection tool should be developed to support future evaluation.

Original languageEnglish
Pages (from-to)E59-E66
JournalJournal of Public Health
Volume42
Issue number1
Early online date3 Apr 2019
DOIs
Publication statusPublished - 1 Mar 2020

Bibliographical note

Funding Information: This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Open Access: No Open Access licence

Publisher Copyright: © Crown copyright 2019.

Citation: Maya Gobin, Gareth Hughes, Sarah Foulkes, Helen Bagnall, Amy Trindall, Valérie Decraene, Obaghe Edeghere, Sooria Balasegaram, Amelia Cummins, Louise Coole, The epidemiology and management of clusters of invasive meningococcal disease in England, 2010–15, Journal of Public Health, Volume 42, Issue 1, March 2020, Pages e58–e65,

DOI: https://doi.org/10.1093/pubmed/fdz028

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