The emerging NDM carbapenemases

Patrice Nordmann; Laurent Poirel; Timothy R. Walsh; David M. Livermore

doi:10.1016/j.tim.2011.09.005

The emerging NDM carbapenemases

Patrice Nordmann^*, Laurent Poirel, Timothy R. Walsh, David M. Livermore

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

533 Citations (Scopus)

Abstract

Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the bla _NDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

Original language	English
Pages (from-to)	588-595
Number of pages	8
Journal	Trends in Microbiology
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2011.09.005
Publication status	Published - Dec 2011

Bibliographical note

Funding Information:
We thank many collaborators worldwide, particularly Thierry Naas, Mark Toleman and Neil Woodford, who have contributed to gain significant knowledge in this field. This work was funded by a grant from INSERM Unité 914, Paris, France.

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10.1016/j.tim.2011.09.005

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title = "The emerging NDM carbapenemases",

abstract = "Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the bla NDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.",

author = "Patrice Nordmann and Laurent Poirel and Walsh, {Timothy R.} and Livermore, {David M.}",

note = "Funding Information: We thank many collaborators worldwide, particularly Thierry Naas, Mark Toleman and Neil Woodford, who have contributed to gain significant knowledge in this field. This work was funded by a grant from INSERM Unit{\'e} 914, Paris, France.",

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AU - Nordmann, Patrice

AU - Poirel, Laurent

AU - Walsh, Timothy R.

AU - Livermore, David M.

N1 - Funding Information: We thank many collaborators worldwide, particularly Thierry Naas, Mark Toleman and Neil Woodford, who have contributed to gain significant knowledge in this field. This work was funded by a grant from INSERM Unité 914, Paris, France.

PY - 2011/12

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N2 - Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the bla NDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

AB - Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the bla NDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

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The emerging NDM carbapenemases

Abstract

Bibliographical note

UN SDGs

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