The efficacy of pertussis vaccines under conditions of household exposure: Further analysis of the 1978-80 phls/erl study in 21 area health authorities in england

Paul E.M. Fine*, Jacqueline A. Clarkson, Elizabeth Miller

*Corresponding author for this work

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    34 Citations (Scopus)

    Abstract

    It has been reported that the efficacy of pertussis vaccines appears to be lower when assessed in household contact studies than when assessed in cohort analyses of general populations. This observation may be attributable in part to methodological factors in home contact studies, in particular to the Inclusion of retrospectively ascertained cases and of households In which the primary case constituted a vaccine failure. These biases are Illustrated using data from a study of the efficacy of pertussis vacdnes carried out by the Public Health Laboratory Service Epidemiological Research Laboratory PHLS/ERL in England during 1978-1980. This analysis reveals several factors which should be considered in the design, analysis and interpretation of household contact studies for evaluation of vaccine efficacy.

    Original languageEnglish
    Pages (from-to)635-642
    Number of pages8
    JournalInternational Journal of Epidemiology
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - Sept 1988

    Bibliographical note

    Funding Information:
    ACKNOWLEDGEMENTS The current analysis was supported by a grant from the Department of Health and Social Security. The authors are grateful to Drs R H Henderson and W A Orenstein for helpful comments.

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