The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate

G. N. Stradling; J. W. Stather; S. A. Gray; J. C. Moody; Michele Ellender; Alan Hodgson; V. Volf; D. M. Taylor; P. Wirth; P. W. Gaskin

doi:10.1080/09553008914551641

The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate

G. N. Stradling^*, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson, V. Volf, D. M. Taylor, P. Wirth, P. W. Gaskin

^*Corresponding author for this work

Radiation Effects

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Abstract

The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing ²³⁸Pu and ²⁴¹Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of ²³⁸Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of ²³⁸Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of ²³⁸Pu plus ²⁴¹Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of ²⁴¹Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

Original language	English
Pages (from-to)	503-514
Number of pages	12
Journal	International Journal of Radiation Biology
Volume	56
Issue number	4
DOIs	https://doi.org/10.1080/09553008914551641
Publication status	Published - 1989

Bibliographical note

Funding Information:
Acknowledgements This work was partly funded by the Commission of the European Communities under research contracts B16-D-089-UK and B16-D-091-D . The pure form of LICAM(C) was synthesized by Dr Burgada and co-workers at the Pierre and Marie Curie University, Paris . We thank Ms K . Wood and Mrs B . Eggmann for animal care .

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Stradling, G. N., Stather, J. W., Gray, S. A., Moody, J. C., Ellender, M., Hodgson, A., Volf, V., Taylor, D. M., Wirth, P., & Gaskin, P. W. (1989). The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate. International Journal of Radiation Biology, 56(4), 503-514. https://doi.org/10.1080/09553008914551641

@article{3fee5c3124f645d6b52fb5b56faa1909,

title = "The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate",

abstract = "The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.",

author = "Stradling, {G. N.} and Stather, {J. W.} and Gray, {S. A.} and Moody, {J. C.} and Michele Ellender and Alan Hodgson and V. Volf and Taylor, {D. M.} and P. Wirth and Gaskin, {P. W.}",

note = "Funding Information: Acknowledgements This work was partly funded by the Commission of the European Communities under research contracts B16-D-089-UK and B16-D-091-D . The pure form of LICAM(C) was synthesized by Dr Burgada and co-workers at the Pierre and Marie Curie University, Paris . We thank Ms K . Wood and Mrs B . Eggmann for animal care .",

year = "1989",

doi = "10.1080/09553008914551641",

language = "English",

volume = "56",

pages = "503--514",

journal = "International Journal of Radiation Biology",

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Stradling, GN, Stather, JW, Gray, SA, Moody, JC, Ellender, M, Hodgson, A, Volf, V, Taylor, DM, Wirth, P & Gaskin, PW 1989, 'The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate', International Journal of Radiation Biology, vol. 56, no. 4, pp. 503-514. https://doi.org/10.1080/09553008914551641

The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate. / Stradling, G. N.; Stather, J. W.; Gray, S. A. et al.
In: International Journal of Radiation Biology, Vol. 56, No. 4, 1989, p. 503-514.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate

AU - Stradling, G. N.

AU - Stather, J. W.

AU - Gray, S. A.

AU - Moody, J. C.

AU - Ellender, Michele

AU - Hodgson, Alan

AU - Volf, V.

AU - Taylor, D. M.

AU - Wirth, P.

AU - Gaskin, P. W.

N1 - Funding Information: Acknowledgements This work was partly funded by the Commission of the European Communities under research contracts B16-D-089-UK and B16-D-091-D . The pure form of LICAM(C) was synthesized by Dr Burgada and co-workers at the Pierre and Marie Curie University, Paris . We thank Ms K . Wood and Mrs B . Eggmann for animal care .

PY - 1989

Y1 - 1989

N2 - The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

AB - The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

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U2 - 10.1080/09553008914551641

DO - 10.1080/09553008914551641

M3 - Article

C2 - 2571662

AN - SCOPUS:0024435994

SN - 0955-3002

VL - 56

SP - 503

EP - 514

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 4

ER -

The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate

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