The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate

G. N. Stradling; J. W. Stather; S. A. Gray; J. C. Moody; M. Ellender; A. Hodgson

doi:10.1016/S0232-1513(89)80020-9

The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate

G. N. Stradling^*
, J. W. Stather
, S. A. Gray
, J. C. Moody
, M. Ellender
, A. Hodgson

^*Corresponding author for this work

Radiation Effects

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

After the inhalation of ²³⁸Pu and ²⁴¹Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of ²³⁸Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	Experimental Pathology
Volume	37
Issue number	1-4
DOIs	https://doi.org/10.1016/S0232-1513(89)80020-9
Publication status	Published - 1989

Bibliographical note

Funding Information:
This work was partly funded by the Commission of the European Communities under research contracts BI6-D-089-UK. LICAM(C) was synthesised by Dr. BURGADA and colleagues at the Pierre and Marie Curie University, Paris. We thank Ms. K. WOOD for animal care.

Keywords

DTPA, inhalation
LICAM(C), inhalation
americium
diethylenetriaminepenta-acetic acid (DTPA)
inhalation DTPA
inhalation LICAM(C)
plutonium

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10.1016/S0232-1513(89)80020-9

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title = "The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate",

abstract = "After the inhalation of 238Pu and 241Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of 238Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.",

keywords = "DTPA, inhalation, LICAM(C), inhalation, americium, diethylenetriaminepenta-acetic acid (DTPA), inhalation DTPA, inhalation LICAM(C), plutonium",

author = "Stradling, \{G. N.\} and Stather, \{J. W.\} and Gray, \{S. A.\} and Moody, \{J. C.\} and M. Ellender and A. Hodgson",

note = "Funding Information: This work was partly funded by the Commission of the European Communities under research contracts BI6-D-089-UK. LICAM(C) was synthesised by Dr. BURGADA and colleagues at the Pierre and Marie Curie University, Paris. We thank Ms. K. WOOD for animal care.",

year = "1989",

doi = "10.1016/S0232-1513(89)80020-9",

language = "English",

volume = "37",

pages = "83--88",

journal = "Experimental Pathology",

issn = "0232-1513",

publisher = "Elsevier B.V.",

number = "1-4",

}

TY - JOUR

T1 - The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate

AU - Stradling, G. N.

AU - Stather, J. W.

AU - Gray, S. A.

AU - Moody, J. C.

AU - Ellender, M.

AU - Hodgson, A.

N1 - Funding Information: This work was partly funded by the Commission of the European Communities under research contracts BI6-D-089-UK. LICAM(C) was synthesised by Dr. BURGADA and colleagues at the Pierre and Marie Curie University, Paris. We thank Ms. K. WOOD for animal care.

PY - 1989

Y1 - 1989

N2 - After the inhalation of 238Pu and 241Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of 238Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.

AB - After the inhalation of 238Pu and 241Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of 238Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.

KW - DTPA, inhalation

KW - LICAM(C), inhalation

KW - americium

KW - diethylenetriaminepenta-acetic acid (DTPA)

KW - inhalation DTPA

KW - inhalation LICAM(C)

KW - plutonium

UR - https://www.scopus.com/pages/publications/0024797021

U2 - 10.1016/S0232-1513(89)80020-9

DO - 10.1016/S0232-1513(89)80020-9

M3 - Article

C2 - 2637176

AN - SCOPUS:0024797021

SN - 0232-1513

VL - 37

SP - 83

EP - 88

JO - Experimental Pathology

JF - Experimental Pathology

IS - 1-4

ER -

The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate

Abstract

Bibliographical note

Keywords

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