The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations

M. Samuel; S. Jose; A. Winston; M. Nelson; M. Johnson; D. Chadwick; M. Fisher; C. Leen; M. Gompels; R. Gilson; F. A. Post; P. Hay; C. A. Sabin; Jonathan Ainsworth; J. Anderson; Abdel Babiker; David Chadwick; Valerie Delpech; Martin Fisher; Brian Gazzard; Richard Gilson; Mark Gompels; Phillip Hay; Margaret Johnson; Stephen Kegg; Clifford Leen; Mark Nelson; Chloe Orkin; Adrian Palfreeman; Deenan Pillay; Memory Sachikonye; Achim Schwenk; John Walsh; Teresa Hill; Susie Huntington; Sophie Jose; Andrew Phillips; Caroline Sabin; Alicia Thornton; David Dunn; Adam Glabay; C. Orkin; N. Garrett; J. Lynch; J. Hand; C. de Souza; M. Fisher; N. Perry; S. Tilbury; D. Churchill; B. Gazzard; M. Nelson; M. Waxman; D. Asboe; S. Mandalia; S. Munshi; H. Korat; M. Poulton; C. Taylor; Z. Gleisner; L. Campbell; R. Gilson; N. Brima; I. Williams; A. Schwenk; J. Ainsworth; C. Wood; S. Miller; M. Johnson; M. Youle; F. Lampe; C. Smith; H. Grabowska; C. Chaloner; D. Puradiredja; J. Walsh; J. Weber; F. Ramzan; N. Mackie; A. Winston; C. Leen; A. Wilson; M. Gompels; S. Allan; A. Palfreeman; A. Moore; D. Chadwick; K. Wakeman; F. Martin; S. Douglas; P. Hay; M. Dhillon

doi:10.1111/hiv.12103

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations

M. Samuel^*, S. Jose, A. Winston, M. Nelson, M. Johnson, D. Chadwick, M. Fisher, C. Leen, M. Gompels, R. Gilson, F. A. Post, P. Hay, C. A. Sabin, Jonathan Ainsworth, J. Anderson, Abdel Babiker, David Chadwick, Valerie Delpech, Martin Fisher, Brian GazzardRichard Gilson, Mark Gompels, Phillip Hay, Margaret Johnson, Stephen Kegg, Clifford Leen, Mark Nelson, Chloe Orkin, Adrian Palfreeman, Deenan Pillay, Memory Sachikonye, Achim Schwenk, John Walsh, Teresa Hill, Susie Huntington, Sophie Jose, Andrew Phillips, Caroline Sabin, Alicia Thornton, David Dunn, Adam Glabay, C. Orkin, N. Garrett, J. Lynch, J. Hand, C. de Souza, M. Fisher, N. Perry, S. Tilbury, D. Churchill, B. Gazzard, M. Nelson, M. Waxman, D. Asboe, S. Mandalia, S. Munshi, H. Korat, M. Poulton, C. Taylor, Z. Gleisner, L. Campbell, R. Gilson, N. Brima, I. Williams, A. Schwenk, J. Ainsworth, C. Wood, S. Miller, M. Johnson, M. Youle, F. Lampe, C. Smith, H. Grabowska, C. Chaloner, D. Puradiredja, J. Walsh, J. Weber, F. Ramzan, N. Mackie, A. Winston, C. Leen, A. Wilson, M. Gompels, S. Allan, A. Palfreeman, A. Moore, D. Chadwick, K. Wakeman, F. Martin, S. Douglas, P. Hay, M. Dhillon

^*Corresponding author for this work

HIV & Aids Reporting

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P<0.001) and haemoglobin (P=0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged <30, 30-50 and >50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively. Conclusions: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age.

Original language	English
Pages (from-to)	311-316
Number of pages	6
Journal	HIV Medicine
Volume	15
Issue number	5
DOIs	https://doi.org/10.1111/hiv.12103
Publication status	Published - 1 Apr 2014

Keywords

Ageing
Albumin
HIV
Haemoglobin
Lipid metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/hiv.12103

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Samuel, M., Jose, S., Winston, A., Nelson, M., Johnson, M., Chadwick, D., Fisher, M., Leen, C., Gompels, M., Gilson, R., Post, F. A., Hay, P., Sabin, C. A., Ainsworth, J., Anderson, J., Babiker, A., Chadwick, D., Delpech, V., Fisher, M., ... Dhillon, M. (2014). The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations. HIV Medicine, 15(5), 311-316. https://doi.org/10.1111/hiv.12103

@article{9c6266b7267f4ba2976e4f30ebd25fd7,

title = "The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations",

abstract = "Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-na{\"i}ve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P<0.001) and haemoglobin (P=0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged <30, 30-50 and >50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively. Conclusions: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age.",

keywords = "Ageing, Albumin, HIV, Haemoglobin, Lipid metabolism",

author = "M. Samuel and S. Jose and A. Winston and M. Nelson and M. Johnson and D. Chadwick and M. Fisher and C. Leen and M. Gompels and R. Gilson and Post, {F. A.} and P. Hay and Sabin, {C. A.} and Jonathan Ainsworth and J. Anderson and Abdel Babiker and David Chadwick and Valerie Delpech and Martin Fisher and Brian Gazzard and Richard Gilson and Mark Gompels and Phillip Hay and Margaret Johnson and Stephen Kegg and Clifford Leen and Mark Nelson and Chloe Orkin and Adrian Palfreeman and Deenan Pillay and Memory Sachikonye and Achim Schwenk and John Walsh and Teresa Hill and Susie Huntington and Sophie Jose and Andrew Phillips and Caroline Sabin and Alicia Thornton and David Dunn and Adam Glabay and C. Orkin and N. Garrett and J. Lynch and J. Hand and {de Souza}, C. and M. Fisher and N. Perry and S. Tilbury and D. Churchill and B. Gazzard and M. Nelson and M. Waxman and D. Asboe and S. Mandalia and S. Munshi and H. Korat and M. Poulton and C. Taylor and Z. Gleisner and L. Campbell and R. Gilson and N. Brima and I. Williams and A. Schwenk and J. Ainsworth and C. Wood and S. Miller and M. Johnson and M. Youle and F. Lampe and C. Smith and H. Grabowska and C. Chaloner and D. Puradiredja and J. Walsh and J. Weber and F. Ramzan and N. Mackie and A. Winston and C. Leen and A. Wilson and M. Gompels and S. Allan and A. Palfreeman and A. Moore and D. Chadwick and K. Wakeman and F. Martin and S. Douglas and P. Hay and M. Dhillon",

year = "2014",

month = apr,

day = "1",

doi = "10.1111/hiv.12103",

language = "English",

volume = "15",

pages = "311--316",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "wiley",

number = "5",

}

Samuel, M, Jose, S, Winston, A, Nelson, M, Johnson, M, Chadwick, D, Fisher, M, Leen, C, Gompels, M, Gilson, R, Post, FA, Hay, P, Sabin, CA, Ainsworth, J, Anderson, J, Babiker, A, Chadwick, D, Delpech, V, Fisher, M, Gazzard, B, Gilson, R, Gompels, M, Hay, P, Johnson, M, Kegg, S, Leen, C, Nelson, M, Orkin, C, Palfreeman, A, Pillay, D, Sachikonye, M, Schwenk, A, Walsh, J, Hill, T, Huntington, S, Jose, S, Phillips, A, Sabin, C, Thornton, A, Dunn, D, Glabay, A, Orkin, C, Garrett, N, Lynch, J, Hand, J, de Souza, C, Fisher, M, Perry, N, Tilbury, S, Churchill, D, Gazzard, B, Nelson, M, Waxman, M, Asboe, D, Mandalia, S, Munshi, S, Korat, H, Poulton, M, Taylor, C, Gleisner, Z, Campbell, L, Gilson, R, Brima, N, Williams, I, Schwenk, A, Ainsworth, J, Wood, C, Miller, S, Johnson, M, Youle, M, Lampe, F, Smith, C, Grabowska, H, Chaloner, C, Puradiredja, D, Walsh, J, Weber, J, Ramzan, F, Mackie, N, Winston, A, Leen, C, Wilson, A, Gompels, M, Allan, S, Palfreeman, A, Moore, A, Chadwick, D, Wakeman, K, Martin, F, Douglas, S, Hay, P & Dhillon, M 2014, 'The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations', HIV Medicine, vol. 15, no. 5, pp. 311-316. https://doi.org/10.1111/hiv.12103

TY - JOUR

T1 - The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations

AU - Samuel, M.

AU - Jose, S.

AU - Winston, A.

AU - Nelson, M.

AU - Johnson, M.

AU - Chadwick, D.

AU - Fisher, M.

AU - Leen, C.

AU - Gompels, M.

AU - Gilson, R.

AU - Post, F. A.

AU - Hay, P.

AU - Sabin, C. A.

AU - Ainsworth, Jonathan

AU - Anderson, J.

AU - Babiker, Abdel

AU - Chadwick, David

AU - Delpech, Valerie

AU - Fisher, Martin

AU - Gazzard, Brian

AU - Gilson, Richard

AU - Gompels, Mark

AU - Hay, Phillip

AU - Johnson, Margaret

AU - Kegg, Stephen

AU - Leen, Clifford

AU - Nelson, Mark

AU - Orkin, Chloe

AU - Palfreeman, Adrian

AU - Pillay, Deenan

AU - Sachikonye, Memory

AU - Schwenk, Achim

AU - Walsh, John

AU - Hill, Teresa

AU - Huntington, Susie

AU - Jose, Sophie

AU - Phillips, Andrew

AU - Sabin, Caroline

AU - Thornton, Alicia

AU - Dunn, David

AU - Glabay, Adam

AU - Orkin, C.

AU - Garrett, N.

AU - Lynch, J.

AU - Hand, J.

AU - de Souza, C.

AU - Fisher, M.

AU - Perry, N.

AU - Tilbury, S.

AU - Churchill, D.

AU - Gazzard, B.

AU - Nelson, M.

AU - Waxman, M.

AU - Asboe, D.

AU - Mandalia, S.

AU - Munshi, S.

AU - Korat, H.

AU - Poulton, M.

AU - Taylor, C.

AU - Gleisner, Z.

AU - Campbell, L.

AU - Gilson, R.

AU - Brima, N.

AU - Williams, I.

AU - Schwenk, A.

AU - Ainsworth, J.

AU - Wood, C.

AU - Miller, S.

AU - Johnson, M.

AU - Youle, M.

AU - Lampe, F.

AU - Smith, C.

AU - Grabowska, H.

AU - Chaloner, C.

AU - Puradiredja, D.

AU - Walsh, J.

AU - Weber, J.

AU - Ramzan, F.

AU - Mackie, N.

AU - Winston, A.

AU - Leen, C.

AU - Wilson, A.

AU - Gompels, M.

AU - Allan, S.

AU - Palfreeman, A.

AU - Moore, A.

AU - Chadwick, D.

AU - Wakeman, K.

AU - Martin, F.

AU - Douglas, S.

AU - Hay, P.

AU - Dhillon, M.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P<0.001) and haemoglobin (P=0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged <30, 30-50 and >50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively. Conclusions: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age.

AB - Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P<0.001) and haemoglobin (P=0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged <30, 30-50 and >50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively. Conclusions: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age.

KW - Ageing

KW - Albumin

KW - HIV

KW - Haemoglobin

KW - Lipid metabolism

UR - http://www.scopus.com/inward/record.url?scp=84897454343&partnerID=8YFLogxK

U2 - 10.1111/hiv.12103

DO - 10.1111/hiv.12103

M3 - Article

C2 - 24245861

AN - SCOPUS:84897454343

SN - 1464-2662

VL - 15

SP - 311

EP - 316

JO - HIV Medicine

JF - HIV Medicine

IS - 5

ER -

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations

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Keywords

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