The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland

Adam Trickey; Sara Croxford; Eva Emanuel; Samreen Ijaz; Matthew Hickman; Joanna Kesten; Clare Thomas; Claire Edmundson; Monica Desai; Peter Vickerman

doi:10.1093/cid/ciac140

The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland

Adam Trickey^*, Sara Croxford, Eva Emanuel, Samreen Ijaz, Matthew Hickman, Joanna Kesten, Clare Thomas, Claire Edmundson, Monica Desai, Peter Vickerman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio =0.24, 95% confidence interval [CI]:. 08-.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

Original language	English
Pages (from-to)	1073-1077
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	75
Issue number	6
DOIs	https://doi.org/10.1093/cid/ciac140
Publication status	Published - 15 Sept 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords

HCV
IDU
high dead space syringes
injecting drugs
low dead space syringes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciac140

Cite this

Trickey, A., Croxford, S., Emanuel, E., Ijaz, S., Hickman, M., Kesten, J., Thomas, C., Edmundson, C., Desai, M., & Vickerman, P. (2022). The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland. Clinical Infectious Diseases, 75(6), 1073-1077. https://doi.org/10.1093/cid/ciac140

@article{43f9e60038284d74af53c56671187224,

title = "The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland",

abstract = "Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio =0.24, 95% confidence interval [CI]:. 08-.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.",

keywords = "HCV, IDU, high dead space syringes, injecting drugs, low dead space syringes",

author = "Adam Trickey and Sara Croxford and Eva Emanuel and Samreen Ijaz and Matthew Hickman and Joanna Kesten and Clare Thomas and Claire Edmundson and Monica Desai and Peter Vickerman",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2022",

month = sep,

day = "15",

doi = "10.1093/cid/ciac140",

language = "English",

volume = "75",

pages = "1073--1077",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "6",

}

Trickey, A, Croxford, S, Emanuel, E, Ijaz, S, Hickman, M, Kesten, J, Thomas, C, Edmundson, C, Desai, M & Vickerman, P 2022, 'The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland', Clinical Infectious Diseases, vol. 75, no. 6, pp. 1073-1077. https://doi.org/10.1093/cid/ciac140

The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland. / Trickey, Adam; Croxford, Sara; Emanuel, Eva et al.
In: Clinical Infectious Diseases, Vol. 75, No. 6, 15.09.2022, p. 1073-1077.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs

T2 - Findings from a National Survey in England, Wales, and Northern Ireland

AU - Trickey, Adam

AU - Croxford, Sara

AU - Emanuel, Eva

AU - Ijaz, Samreen

AU - Hickman, Matthew

AU - Kesten, Joanna

AU - Thomas, Clare

AU - Edmundson, Claire

AU - Desai, Monica

AU - Vickerman, Peter

PY - 2022/9/15

Y1 - 2022/9/15

N2 - Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio =0.24, 95% confidence interval [CI]:. 08-.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

AB - Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio =0.24, 95% confidence interval [CI]:. 08-.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

KW - HCV

KW - IDU

KW - high dead space syringes

KW - injecting drugs

KW - low dead space syringes

UR - http://www.scopus.com/inward/record.url?scp=85139379259&partnerID=8YFLogxK

U2 - 10.1093/cid/ciac140

DO - 10.1093/cid/ciac140

M3 - Article

C2 - 35184173

AN - SCOPUS:85139379259

SN - 1058-4838

VL - 75

SP - 1073

EP - 1077

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 6

ER -

The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition among People Who Inject Drugs: Findings from a National Survey in England, Wales, and Northern Ireland

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this